Journal article
Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (β-Lactones)
Abstract
A homologous series of both C3-unsubstituted and C3-methyl substituted oxetan-2-ones (beta-lactones) was investigated as potential inhibitors of yeast 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase. Several reported methods for racemic beta-lactone synthesis were studied for preparation of the target series. In addition, a novel aluminum-based Lewis acid obtained by combination of Et2AlCl with (1R,2R)-2-[(diphenyl)hydroxymethyl] …
Authors
Romo D; Harrison PHM; Jenkins SI; Riddoch RW; Park K; Yang HW; Zhao C; Wright GD
Journal
Bioorganic & Medicinal Chemistry, Vol. 6, No. 8, pp. 1255–1272
Publisher
Elsevier
Publication Date
August 1998
DOI
10.1016/s0968-0896(98)00114-x
ISSN
0968-0896