Synthesis of non-nucleoside anti-viral...

Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies

Abstract

The synthesis of a lead anti-viral cyclopropyl carboxy acyl hydrazone 4F17 (5) and three sequential arrays of structural analogues along with the initial assessment and optimization of the antiviral pharmacophore against the herpes simplex virus type 1 (HSV-1) are reported.

Authors

McNulty J; Babu Dokuburra C; D'Aiuto L; Demers M; McClain L; Piazza P; Williamson K; Zheng W; Nimgaonkar VL

Journal

Bioorganic & Medicinal Chemistry Letters, Vol. 30, No. 24,

Publisher

Elsevier

Publication Date

December 15, 2020

DOI

10.1016/j.bmcl.2020.127559

ISSN

0960-894X

Associated Experts

James Mcnulty

Professor, Faculty of Science

Visit profile

Labels