Journal article
Intermolecular crosslinking of fatty acyl chains in phospholipids: use of photoactivable carbene precursors.
Abstract
Phospholipids containing photolysable carbene precursors (beta-trifluoro-alpha-diazopropionoxy and m-diazirinophenoxy groups) in omega-positions of sn-2 fatty acyl chains were prepared. Photolysis of their vesicles produced crosslinked products in 40-60% yields. Crosslinking was mostly intermolecular and occurred by carbene insertion into the C-H bonds of a second fatty acyl chain. Crosslinking products were characterized by (i) their gel …
Authors
Gupta CM; Radhakrishnan R; Gerber GE; Olsen WL; Quay SC; Khorana HG
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 76, No. 6, pp. 2595–2599
Publisher
Proceedings of the National Academy of Sciences
Publication Date
June 1979
DOI
10.1073/pnas.76.6.2595
ISSN
0027-8424