Journal article
Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model
Abstract
The ErbB-2/Neu receptor tyrosine kinase plays a causal role in tumorigenesis in mammals. Neu's carboxyl terminus contains five phosphorylated tyrosines that mediate transformation through interaction with cytoplasmic SH2 or PTB containing adaptor proteins. We show that Drosophila adaptors signal from individual phosphotyrosine sites of rat Neu. Activated Neu expression in the midline glia suppressed apoptosis, similar to that seen with …
Authors
Settle M; Gordon MD; Nadella M; Dankort D; Muller W; Jacobs JR
Journal
Oncogene, Vol. 22, No. 13, pp. 1916–1926
Publisher
Springer Nature
Publication Date
April 3, 2003
DOI
10.1038/sj.onc.1206240
ISSN
0950-9232
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptor Proteins, Vesicular TransportAnimalsAnimals, Genetically ModifiedApoptosisDrosophila ProteinsDrosophila melanogasterErbB ReceptorsEyeEye ProteinsGene DosageGene Expression Regulation, DevelopmentalMorphogenesisNerve Tissue ProteinsPhenotypePhosphorylationPhosphotyrosineProtein KinasesProtein Processing, Post-TranslationalProtein Structure, TertiaryProtein Tyrosine PhosphatasesProtein Tyrosine Phosphatases, Non-ReceptorProteinsProto-Oncogene Proteins c-rafRatsReceptor, ErbB-2Receptors, Invertebrate PeptideRecombinant Fusion ProteinsShc Signaling Adaptor ProteinsSignal TransductionSon of Sevenless Protein, DrosophilaStructure-Activity RelationshipWings, Animal