4-Aryl-3-(hydroxyalkyl)quinolin-2-ones:  Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction Academic Article uri icon

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abstract

  • Novel 4-aryl-3-(hydroxyalkyl)quinoline-2-one derivatives were prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on corporal smooth muscle was studied in vitro using isolated rabbit corpus cavernosum. From this study, a potent maxi-K opener was identified as an effective relaxant of rabbit corporal smooth muscle and shown to be active in an in vivo animal model of male erectile function.

authors

  • Hewawasam, Piyasena
  • Fan, Wenhong
  • Ding, Min
  • Flint, Kim
  • Cook, Deborah
  • Goggins, Gregory D
  • Myers, Robert A
  • Gribkoff, Valentin K
  • Boissard, Christopher G
  • Dworetzky, Steven I
  • Starrett,, John E
  • Lodge, Nicholas J

publication date

  • July 2003

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