Journal article
Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
Abstract
The AMP-activated protein kinase (AMPK) is a metabolic stress-sensing αβγ heterotrimer responsible for energy homeostasis, making it a therapeutic target for metabolic diseases such as type 2 diabetes and obesity. AMPK signaling is triggered by phosphorylation on the AMPK α subunit activation loop Thr172 by upstream kinases. Dephosphorylated, naive AMPK is thought to be catalytically inactive and insensitive to allosteric regulation by AMP and …
Authors
Scott JW; Ling N; Issa SMA; Dite TA; O’Brien MT; Chen Z-P; Galic S; Langendorf CG; Steinberg GR; Kemp BE
Journal
Cell Chemical Biology, Vol. 21, No. 5, pp. 619–627
Publisher
Elsevier
Publication Date
May 2014
DOI
10.1016/j.chembiol.2014.03.006
ISSN
2451-9456