Journal article
Organometallic Antitumor Compounds: Ferrocifens as Precursors to Quinone Methides
Abstract
The synthesis and chemical oxidation profile of a new generation of ferrocifen derivatives with strong antiproliferative behavior in vitro is reported. In particular, the hydroxypropyl derivative HO(CH2 )3 C(Fc)=C(C6 H4 OH)2 (3 b) exhibited exceptional antiproliferative activity against the cancer cell lines HepG2 and MDA-MB-231 TNBC, with IC50 values of 0.07 and 0.11 μM, respectively. Chemical oxidation of 3 b yielded an unprecedented …
Authors
Wang Y; Pigeon P; Top S; McGlinchey MJ; Jaouen G
Journal
Angewandte Chemie International Edition, Vol. 54, No. 35, pp. 10230–10233
Publisher
Wiley
Publication Date
August 24, 2015
DOI
10.1002/anie.201503048
ISSN
1433-7851