Journal article
Are the pharmacological effects of L-prolyl-L-leucylglycinamide (PLG) mediated through specific receptor mechanisms?
Abstract
In an attempt to delineate the mechanism subserving the demonstrated central effects of the tripeptide, L-prolyl-L-leucyl-glycinamide (PLG) in mammals including humans, we developed a radioligand binding assay to characterize the binding of 3H-PLG to rat brain membranes. Equilibrium binding studies indicated that PLG binds to rat striatum with high affinity (KD = 4.69 +/- 0.50 nM), saturability (Bmax = 9.20 +/- 0.30 fmoles mg-1 protein) and …
Authors
Simon C; Yu-Wah W; Wan YP; Chiu P; Mishra RK
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 7, No. 4-6, pp. 739–742
Publisher
Elsevier
Publication Date
1 1983
DOI
10.1016/0278-5846(83)90056-8
ISSN
0278-5846