Journal article
Lanthionine−Somatostatin Analogs: Synthesis, Characterization, Biological Activity, and Enzymatic Stability Studies
Abstract
A series of cyclic somatostatin analogs containing a lanthionine bridge have been subjected to studies of structure-activity relationships. A direct synthesis of the thioether bridged analog (1) of sandostatin (SMS 201,995) and several lanthionine hexa-, hepta-, and octapeptides was carried out by using the method of cyclization on an oxime resin (PCOR) followed by condensation reactions in solution. The structures of the target peptides were …
Authors
Ösapay G; Prokai L; Kim H-S; Medzihradszky KF; Coy DH; Liapakis G; Reisine T; Melacini G; Zhu Q; Wang SH-H
Journal
Journal of Medicinal Chemistry, Vol. 40, No. 14, pp. 2241–2251
Publisher
American Chemical Society (ACS)
Publication Date
July 1, 1997
DOI
10.1021/jm960850i
ISSN
0022-2623