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Palmitoyl‐dl‐Carnitine is a Multitarget Inhibitor...
Journal article

Palmitoyl‐dl‐Carnitine is a Multitarget Inhibitor of Pseudomonas aeruginosa Biofilm Development

Abstract

Bacteria growing in biofilms are often in metabolic and physiological states that do not respond well to antibiotics, and thus, are major contributors to chronic diseases. Biofilm inhibitors, therefore, have the potential to be used alone or as adjuvants to conventional antibiotic therapies. Here, we screened a chemically diverse collection of protein kinase inhibitors for molecules that perturb biofilm development. Among the inhibitory …

Authors

Wenderska IB; Chong M; McNulty J; Wright GD; Burrows LL

Journal

ChemBioChem, Vol. 12, No. 18, pp. 2759–2766

Publisher

Wiley

Publication Date

December 16, 2011

DOI

10.1002/cbic.201100500

ISSN

1439-4227