Journal article
A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor
Abstract
Human HtrA2 is part of the HtrA family of ATP-independent serine proteases that are conserved in both prokaryotes and eukaryotes and localizes to the intermembrane space of the mitochondria. Several recent reports have suggested that HtrA2 is important for maintaining proper mitochondrial homeostasis and may play a role in Alzheimer's disease (AD), which is characterized by the presence of aggregates of the amyloid-beta peptide 1-42 …
Authors
Kooistra J; Milojevic J; Melacini G; Ortega J
Journal
Journal of Alzheimer’s Disease, Vol. 17, No. 2, pp. 281–294
Publisher
SAGE Publications
Publication Date
2009
DOI
10.3233/jad-2009-1037
ISSN
1387-2877
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amyloid beta-PeptidesCitrate (si)-SynthaseHigh-Temperature Requirement A Serine Peptidase 2HumansMagnetic Resonance SpectroscopyMicroscopy, Electron, TransmissionMitochondrial ProteinsMutagenesis, Site-DirectedPDZ DomainsPeptide FragmentsProtein BindingSerine EndopeptidasesStructure-Activity RelationshipSubstrate SpecificityTime Factors