Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity Academic Article uri icon

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abstract

  • A series of amidoheteroaryl compounds were designed and synthesized as inhibitors of B-Raf kinase. Several compounds from the series show excellent potency in biochemical, phenotypic and mode of action cellular assays. Potent examples from the series have also demonstrated good plasma exposure following an oral dose in rodents and activity against the Ras-Raf pathway in tumor bearing mice.

authors

  • Lyne, Paul D
  • Aquila, Brian
  • Cook, Donald J
  • Dakin, Les A
  • Ezhuthachan, Jay
  • Ioannidis, Stephanos
  • Pontz, Timothy
  • Su, Mei
  • Ye, Qing
  • Zheng, Xiaolan
  • Block, Michael H
  • Cowen, Scott
  • Deegan, Tracy L
  • Lee, John
  • Scott, David A
  • Custeau, Dominique
  • Drew, Lisa
  • Poondru, Srinivasu
  • Shen, Minhui
  • Wu, Allan

publication date

  • February 2009

has subject area