Acyclic model peptides with ionophoretic activity. Pr3+ transport by N-tBoc-Pro-Xxx-Ala-NHCH3. Journal Articles uri icon

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abstract

  • Two linear synthetic peptides, N-tBoc-Pro-Gly-Ala-NHCH3 and N-tBoc-Pro-D-Ala-Ala-NHCH3, have previously been shown by us to complex with Ca2+ and form 2:1 (peptide:calcium) complexes. Here we report their binding to Pr3+ and demonstrate, by 1H NMR, the peptide-mediated transport of Pr3+ across dimyristoylphosphatidylcholine unilamellar vesicles via a 2:1 ion-sandwich complex.

publication date

  • May 5, 1986