Mice, Transgenic Concept

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• In VivoMagnetic Resonance Imaging and Semiautomated Image Analysis Extend the Brain Phenotype forcdf/cdfMice  Journal Articles
• Pseudomonas aeruginosaLasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator–IL-6–antimicrobial–repair pathway  Journal Articles
• A Dietary Supplement Abolishes Age-Related Cognitive Decline in Transgenic Mice Expressing Elevated Free Radical Processes  Journal Articles
• A Double Recombinant Adenovirus Expressing the Costimulatory Molecule B7-1 (Murine) and Human IL-2 Induces Complete Tumor Regression in a Murine Breast Adenocarcinoma Model  Journal Articles
• A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells  Journal Articles
• A Phase I Study of Adenovirus Mediated Gene Transfer of Interleukin 2 cDNA into Metastatic Breast Cancer or Melanoma. The Toronto Hospital, Toronto, Ontario, Canada  Journal Articles
• A Study of the Purine Derivative AIT-082 in G93A SOD1 Transgenic Mice  Journal Articles
• A Transgenic Mouse Model to Study Glucose Transporter 4myc Regulation in Skeletal Muscle  Journal Articles
• A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging  Journal Articles
• A huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington's disease  Journal Articles
• A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells  Journal Articles
• A multi‐ingredient dietary supplement abolishes large‐scale brain cell loss, improves sensory function, and prevents neuronal atrophy in aging mice  Journal Articles
• A novel GFP reporter mouse reveals Mustn1 expression in adult regenerating skeletal muscle, activated satellite cells and differentiating myoblasts  Journal Articles
• A novel profibrotic mechanism mediated by TGFβ‐stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells  Journal Articles
• A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor α expressed from an adenovirus vector induces an antitumor response with reduced toxicity  Journal Articles
• A transgenic mouse line harboring a smooth muscle alpha-actin promoter polyomavirus middle T antigen transgene develops an epithelial hyperplasia in the rectum and distal stomach.  Journal Articles
• A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis  Journal Articles
• AMPK as a Therapeutic Target for Treating Metabolic Diseases  Journal Articles
• AMPK-Dependent Inhibitory Phosphorylation of ACC Is Not Essential for Maintaining Myocardial Fatty Acid Oxidation  Journal Articles
• AMPK‐independent pathways regulate skeletal muscle fatty acid oxidation  Journal Articles
• AP‐2α is required after lens vesicle formation to maintain lens integrity  Journal Articles
• Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology  Journal Articles
• Abrogation of mesenchyme-specific TGF-β signaling results in lung malformation with prenatal pulmonary cysts in mice  Journal Articles
• Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity  Journal Articles
• Activated calcineurin ameliorates contraction‐induced injury to skeletal muscles of mdx dystrophic mice  Journal Articles
• Activation of the Hedgehog Signaling Pathway in the Developing Lens Stimulates EctopicFoxE3Expression and Disruption in Fiber Cell Differentiation  Journal Articles
• Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models  Journal Articles
• Adenoviral vector-mediated GM-CSF gene transfer improves anti-mycobacterial immunity in mice – role of regulatory T cells  Journal Articles
• Adenylyl Cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice  Journal Articles
• Aerobic training as an adjunctive therapy to enzyme replacement in Pompe disease  Journal Articles
• Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis.  Journal Articles
• An Intact Intermediate Filament Network Is Required for Collateral Sprouting of Small Diameter Nerve Fibers  Journal Articles
• An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene  Journal Articles
• An aptamer‐based magnetic resonance imaging contrast agent for detecting oligomeric amyloid‐β in the brain of an Alzheimer's disease mouse model  Journal Articles
• An upstream region of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice.  Journal Articles
• Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection  Journal Articles
• Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk  Journal Articles
• Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin  Journal Articles
• Antigen Presentation by Exosomes Released from Peptide-Pulsed Dendritic Cells Is not Suppressed by the Presence of Active CTL  Journal Articles
• Antigen Specificity Acquisition of Adoptive CD4+ Regulatory T Cells via Acquired Peptide-MHC Class I Complexes  Journal Articles
• Astrocytes Prevent Abnormal Neuronal Development in the Fragile X Mouse  Journal Articles
• Autoimmune Manifestations in the 3xTg-AD Model of Alzheimer's Disease  Journal Articles
• BL-7010 Demonstrates Specific Binding to Gliadin and Reduces Gluten-Associated Pathology in a Chronic Mouse Model of Gliadin Sensitivity  Journal Articles
• BMP Receptor ALK3 Controls Collecting System Development  Journal Articles
• Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax  Journal Articles
• Beneficial effect of ginseng root in SOD-1 (G93A) transgenic mice  Journal Articles
• Black Cohosh Increases Metastatic Mammary Cancer in Transgenic Mice Expressing c-erbB2  Journal Articles
• CD11c+ antigen presenting cells from the alveolar space, lung parenchyma and spleen differ in their phenotype and capabilities to activate naïve and antigen-primed T cells  Journal Articles
• CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control  Journal Articles
• Calcineurin-Aα activation enhances the structure and function of regenerating muscles after myotoxic injury  Journal Articles
• Caloric Restriction Shortens Lifespan through an Increase in Lipid Peroxidation, Inflammation and Apoptosis in the G93A Mouse, an Animal Model of ALS  Journal Articles
• Caloric restriction transiently improves motor performance but hastens clinical onset of disease in the Cu/Zn‐superoxide dismutase mutant G93A mouse  Journal Articles
• Carotid Body: New Stimuli and New Preparations – Invited Article  Journal Articles
• Cellular and Molecular Regulation of Skeletal Muscle Side Population Cells  Journal Articles
• Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake  Journal Articles
• Ceramide Is Responsible for the Failure of Compensatory Nerve Sprouting in Apolipoprotein E Knock-Out Mice  Journal Articles
• Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio and ameliorates the cholinergic deficit in a transgenic model of Alzheimer's disease  Journal Articles
• Characterization of a Mouse Model for Thrombomodulin Deficiency  Journal Articles
• Characterization of a Novel Primary Mammary Tumor Cell Line Reveals that Cyclin D1 Is Regulated by the Type I Insulin-Like Growth Factor Receptor  Journal Articles
• Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis  Journal Articles
• Characterization of the effects of exercise training on hematopoietic stem cell quantity and function  Journal Articles
• Characterizing Complex Polysera Produced by Antigen-Specific Immunization through the Use of Affinity-Selected Mimotopes  Journal Articles
• Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53  Journal Articles
• Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology  Journal Articles
• Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice  Journal Articles
• Chronic AMPK stimulation attenuates adaptive signaling in dystrophic skeletal muscle  Journal Articles
• Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase–Dependent Pathway That Is Impaired With Obesity  Journal Articles
• Circuit Mechanisms Underlying Motor Memory Formation in the Cerebellum  Journal Articles
• Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity  Journal Articles
• Combination Therapy with Interleukin-2 and Wild-Type p53 Expressed by Adenoviral Vectors Potentiates Tumor Regression in a Murine Model of Breast Cancer  Journal Articles
• Combined Treatment of a Murine Breast Cancer Model with Type 5 Adenovirus Vectors Expressing Murine Angiostatin and IL-12: A Role for Combined Anti-Angiogenesis and Immunotherapy  Journal Articles
• Combining Oncolytic HSV-1 with Immunogenic Cell Death-Inducing Drug Mitoxantrone Breaks Cancer Immune Tolerance and Improves Therapeutic Efficacy  Journal Articles
• Compromised genomic integrity impedes muscle growth after Atrx inactivation  Journal Articles
• Conditional Deletion of AP-2α and AP-2β in the Developing Murine Retina Leads to Altered Amacrine Cell Mosaics and Disrupted Visual Function  Journal Articles
• Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent  Journal Articles
• Control of Motoneuron Survival by Angiogenin  Journal Articles
• Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice  Journal Articles
• Critical Negative Regulation of Type 1 T Cell Immunity and Immunopathology by Signaling Adaptor DAP12 during Intracellular Infection  Journal Articles
• Crosstalk between Notch and Sonic hedgehog signaling in a mouse model of amyotrophic lateral sclerosis  Journal Articles
• Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL−/− mice: Support for a role for TDP-43 in the physiological response to neuronal injury  Journal Articles
• Cytosolic localization of Fox proteins in motor neurons of G93A SOD1 mice  Journal Articles
• De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors  Journal Articles
• De novo pathogenic variant in SETX causes a rapidly progressive neurodegenerative disorder of early childhood-onset with severe axonal polyneuropathy  Journal Articles
• Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease  Journal Articles
• Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice  Journal Articles
• Delivery of viral-vectored vaccines by B cells represents a novel strategy to accelerate CD8+ T-cell recall responses  Journal Articles
• Demyelination in a transgenic mouse: A model for multiple sclerosis  Journal Articles
• Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells  Journal Articles
• Developmental and Lactational Exposure to Dieldrin Alters Mammary Tumorigenesis in Her2/neu Transgenic Mice  Journal Articles
• Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration  Journal Articles
• Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging  Journal Articles
• Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer’s disease-associated markers in 3xTg-AD mice  Journal Articles
• Differentiation of bone marrow-derived cells into regenerated mesothelial cells in peritoneal remodeling using a peritoneal fibrosis mouse model  Journal Articles
• Discovery of Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for Live-Cell and In Vivo Imaging  Journal Articles
• Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling  Journal Articles
• Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice.  Journal Articles
• Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2  Journal Articles
• ER Stress and Lipogenesis: A Slippery Slope toward Hepatic Steatosis  Journal Articles
• Early Intervention with a Multi-Ingredient Dietary Supplement Improves Mood and Spatial Memory in a Triple Transgenic Mouse Model of Alzheimer’s Disease  Journal Articles
• Ectopic Expression of AP-2α Transcription Factor in the Lens Disrupts Fiber Cell Differentiation  Journal Articles
• Effect of covalent antithrombin-heparin complex on developmental mechanisms in the lung  Journal Articles
• Effects of Creatine and Exercise on Skeletal Muscle of FRG1-Transgenic Mice  Journal Articles
• Effects of Salt Loading on the Morphology of Astrocytes in the Ventral Glia Limitans of the Rat Supraoptic Nucleus  Journal Articles
• Effects of high‐intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis  Journal Articles
• Electroporation Enables Plasmid Vaccines to Elicit CD8+ T Cell Responses in the Absence of CD4+ T Cells  Journal Articles
• Elevated Blood Pressure in Transgenic Lipoatrophic Mice and Altered Vascular Function  Journal Articles
• Elevated DNA damage in a mouse model of oxidative stress: impacts of ionizing radiation and a protective dietary supplement  Journal Articles
• Embryonic and Neonatal Phenotyping of Genetically Engineered Mice  Journal Articles
• Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation  Journal Articles
• Endothelial Nitric Oxide Synthase Promotes Bone Marrow Stromal Cell Migration to the Ischemic Myocardium via Upregulation of Stromal Cell-Derived Factor-1α    Journal Articles
• Endothelial cell tumors develop in transgenic mice carrying polyoma virus middle T oncogene  Journal Articles
• Energy-stress-mediated AMPK activation inhibits ferroptosis  Journal Articles
• Enhanced Interleukin-2 Gene Transfer Immunotherapy of Breast Cancer by Coexpression of B7-1 and B7-2  Journal Articles
• Eosinophil-derived IL-13 promotes emphysema  Journal Articles
• Eosinophils and T Lymphocytes Possess Distinct Roles in Bleomycin-Induced Lung Injury and Fibrosis  Journal Articles
• ErbB2 Is Required for Muscle Spindle and Myoblast Cell Survival  Journal Articles
• Estradiol Promotes Growth and Angiogenesis in Polyoma Middle T Transgenic Mouse Mammary Tumor Explants  Journal Articles
• Ethylenecarbodiimide-Fixed Donor Splenocyte Infusions Differentially Target Direct and Indirect Pathways of Allorecognition for Induction of Transplant Tolerance  Journal Articles
• Expanded CD56superbrightCD16+ NK Cells from Ovarian Cancer Patients Are Cytotoxic against Autologous Tumor in a Patient-Derived Xenograft Murine Model  Journal Articles
• Expression of Dual TCR on DO11.10 T Cells Allows for Ovalbumin-Induced Oral Tolerance to Prevent T Cell-Mediated Colitis Directed against Unrelated Enteric Bacterial Antigens  Journal Articles
• Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3  Journal Articles
• Factors influencing therapeutic efficacy and the host immune response to helper‐dependent adenoviral gene therapy in hemophilia A mice  Journal Articles
• Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues  Journal Articles
• Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.  Journal Articles
• GLI3 Repressor Controls Nephron Number via Regulation of Wnt11 and Ret in Ureteric Tip Cells  Journal Articles
• GM-CSF Transgene-Based Adjuvant Allows the Establishment of Protective Mucosal Immunity Following Vaccination with Inactivated Chlamydia trachomatis  Journal Articles
• GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia  Journal Articles
• Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer  Journal Articles
• Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice  Journal Articles
• Gluten-Dependent Activation of CD4+ T Cells by MHC Class II–Expressing Epithelium  Journal Articles
• Glycogen Synthase Kinase 3α Deficiency Attenuates Atherosclerosis and Hepatic Steatosis in High Fat Diet–Fed Low Density Lipoprotein Receptor–Deficient Mice  Journal Articles
• Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation  Journal Articles
• Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures  Journal Articles
• Heparan sulfate: Antithrombotic or not?  Journal Articles
• Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury  Journal Articles
• High-Grade Glioma Formation Results from Postnatal Pten Loss or Mutant Epidermal Growth Factor Receptor Expression in a Transgenic Mouse Glioma Model  Journal Articles
• Histological assessment of intermediate- and long-term creatine monohydrate supplementation in mice and rats  Journal Articles
• Host-specific differences in the physiology of acid secretion related to prostaglandins may play a role in gastric inflammation and injury  Journal Articles
• Hsp72 preserves muscle function and slows progression of severe muscular dystrophy  Journal Articles
• Humanized mice are susceptible to Salmonella typhi infection  Journal Articles
• Humanized mouse models of KRAS-mutated colorectal and pancreatic cancers with HLA-class-I match for pre-clinical evaluation of cancer immunotherapies.  Journal Articles
• Identification of T-lymphocytic leukemia–initiating stem cells residing in a small subset of patients with acute myeloid leukemic disease  Journal Articles
• Identification of a Karyopherin β1/β2 Proline-Tyrosine Nuclear Localization Signal in Huntingtin Protein  Journal Articles
• Impaired c-src activation and motility defects in PEA3-null fibroblasts  Journal Articles
• In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer  Journal Articles
• Increased Bacterial Translocation in Gluten-Sensitive Mice Is Independent of Small Intestinal Paracellular Permeability Defect  Journal Articles
• Increased proliferation of hepatic periportal ductal progenitor cells contributes to persistent hypermetabolism after trauma  Journal Articles
• Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity  Journal Articles
• Inhalation Tolerance Is Induced Selectively in Thoracic Lymph Nodes but Executed Pervasively at Distant Mucosal and Nonmucosal Tissues  Journal Articles
• Inhibition of Metabotropic Glutamate Receptor Signaling by the Huntingtin-binding Protein Optineurin  Journal Articles
• Innate immunity in amyotrophic lateral sclerosis  Journal Articles
• Insulin-like Growth Factor II Signaling in Neoplastic Proliferation Is Blocked by Transgenic Expression of the Metalloproteinase Inhibitor Timp-1  Journal Articles
• Integrin-linked kinase regulates process extension in oligodendrocytes via control of actin cytoskeletal dynamics.  Journal Articles
• Interferon-λ Mediates Oral Tolerance and Inhibits Antigen-Specific, T-Helper 2 Cell–Mediated Inflammation in Mouse Intestine  Journal Articles
• Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression  Journal Articles
• Interleukin-15 Modulates Adipose Tissue by Altering Mitochondrial Mass and Activity  Journal Articles
• Interleukin-15 expression affects homeostasis and function of B cells through NK cell-derived interferon-γ  Journal Articles
• Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors  Journal Articles
• Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model.  Journal Articles
• Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia  Journal Articles
• Invariant NKT cells sustain specific B cell responses and memory  Journal Articles
• Kaiso differentially regulates components of the Notch signaling pathway in intestinal cells  Journal Articles
• Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T-cell memory development  Journal Articles
• Larazotide acetate regulates epithelial tight junctions in vitro and in vivo  Journal Articles
• Lens-Specific Expression of TGF-β Induces Anterior Subcapsular Cataract Formation in the Absence of Smad3  Journal Articles
• Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice  Journal Articles
• Loss of Wasl improves pancreatic cancer outcome  Journal Articles
• Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer's disease mouse model.  Journal Articles
• MMP9 Differentially Regulates Proteins Involved in Actin Polymerization and Cell Migration during TGF-β-Induced EMT in the Lens  Journal Articles
• Male Sexual Dysfunction in Mice Bearing Targeted Mutant Alleles of thePEA3 etsGene  Journal Articles
• Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo  Journal Articles
• Matrix Metalloproteinase-9–Null Mice Are Resistant to TGF-β–Induced Anterior Subcapsular Cataract Formation  Journal Articles
• Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes  Journal Articles
• Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13  Journal Articles
• Modulation of Hepatic Granulomatous Responses by Transgene Expression of DAP12 or TREM-1-Ig Molecules  Journal Articles
• Molecular Cloning and Cell-Free Expression of Mouse Antithrombin III  Journal Articles
• Molecular imaging of nuclear factor-Y transcriptional activity maps proliferation sites in live animals  Journal Articles
• Mouse phenogenomics, toolbox for functional annotation of human genome  Journal Articles
• MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot–Marie–Tooth disease type 1B  Journal Articles
• Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4  Journal Articles
• Muscle satellite cell and atypical myogenic progenitor response following exercise  Journal Articles
• Muscle-specific overexpression of IGF-I improves E-C coupling in skeletal muscle fibers from dystrophic mdx mice  Journal Articles
• N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation  Journal Articles
• NGF over-expression during development leads to permanent alterations in innervation in the spinal cord and in behavioural responses to sensory stimuli  Journal Articles
• Neoplastic human embryonic stem cells as a model of radiation resistance of human cancer stem cells  Journal Articles
• Nerve growth factor promoter activity revealed in mice expressing enhanced green fluorescent protein  Journal Articles
• Neurotrophic activity of proNGF in vivo  Journal Articles
• Notch-Induced miR-708 Antagonizes Satellite Cell Migration and Maintains Quiescence  Journal Articles
• ORIGINAL ARTICLE: LPS‐Induced Murine Abortions Require C5 but not C3, and are Prevented by Upregulating Expression of the CD200 Tolerance Signaling Molecule  Journal Articles
• Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak-/- Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure  Journal Articles
• Object recognition memory and BDNF expression are reduced in young TgCRND8 mice  Journal Articles
• One Universal Common Endpoint in Mouse Models of Amyotrophic Lateral Sclerosis  Journal Articles
• Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection  Journal Articles
• Overexpression of Tumor Necrosis Factor-α Diminishes Pulmonary Fibrosis Induced by Bleomycin or Transforming Growth Factor-β  Journal Articles
• Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia.  Journal Articles
• Overexpression of nerve growth factor by murine smooth muscle cells: Role of the p75 neurotrophin receptor on sympathetic and sensory sprouting  Journal Articles
• Oxidative stress and antioxidant enzyme upregulation in SOD1‐G93A mouse skeletal muscle  Journal Articles
• PEA3 is overexpressed in mouse metastatic mammary adenocarcinomas.  Journal Articles
• PGC‐1α gene expression is down‐regulated by Akt‐mediated phosphorylation and nuclear exclusion of FoxO1 in insulin‐stimulated skeletal muscle  Journal Articles
• Pathway Pathology  Journal Articles
• Peptide immunotherapy in allergic asthma generates IL-10–dependent immunological tolerance associated with linked epitope suppression  Journal Articles
• Plasma fibronectin supports hemostasis and regulates thrombosis  Journal Articles
• Polymeric Binders Suppress Gliadin-Induced Toxicity in the Intestinal Epithelium  Journal Articles
• Preneoplastic changes persist after IGF-IR downregulation and tumor regression  Journal Articles
• Propagating factor IX-producing hepatocytes for haemophilia B therapy  Journal Articles
• Proteolytic Cleavage of Ataxin-7 by Caspase-7 Modulates Cellular Toxicity and Transcriptional Dysregulation  Journal Articles
• Purine receptor antagonist modulates serology and affective behaviors in lupus-prone mice: Evidence of autoimmune-induced pain?  Journal Articles
• Quebec platelet disorder  Journal Articles
• Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise  Journal Articles
• Radiation-induced apoptosis in mouse lymphocytes is modified by a complex dietary supplement: the effect of genotype and gender  Journal Articles
• Receptors for non-MHC ligands contribute to uterine natural killer cell activation during pregnancy in mice  Journal Articles
• Recombinant Adenovirus Vaccines Can Successfully Elicit CD8+ T Cell Immunity under Conditions of Extreme Leukopenia  Journal Articles
• Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity  Journal Articles
• Reduced Tissue Levels of Noradrenaline Are Associated with Behavioral Phenotypes of the TgCRND8 Mouse Model of Alzheimer's Disease  Journal Articles
• Relative Reduction of Endothelial Nitric-Oxide Synthase Expression and Transcription in Atherosclerosis-Prone Regions of the Mouse Aorta and in an in Vitro Model of Disturbed Flow  Journal Articles
• Requirement for Both Shc and Phosphatidylinositol 3′ Kinase Signaling Pathways in Polyomavirus Middle T-Mediated Mammary Tumorigenesis  Journal Articles
• Respiratory macrophages regulate CD4 T memory responses to mucosal immunization with recombinant adenovirus-based vaccines  Journal Articles
• Restoration of Vitamin C Synthesis in Transgenic Gulo^−/− Mice by Helper-Dependent Adenovirus-Based Expression of Gulonolactone Oxidase  Journal Articles
• Restoration of innate immune activation accelerates Th1‐cell priming and protection following pulmonary mycobacterial infection  Journal Articles
• Reversibility and recurrence of IGF-IR-induced mammary tumors  Journal Articles
• Role of CD200 expression in regulation of metastasis of EMT6 tumor cells in mice  Journal Articles
• Role of STAT6 and SMAD2 in a model of chronic allergen exposure: a mouse strain comparison study  Journal Articles
• SOX2, a Persistent Marker for Multipotential Neural Stem Cells Derived from Embryonic Stem Cells, the Embryo or the Adult  Journal Articles
• Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR α‐chain CDR3 loop  Journal Articles
• Sensitization to Gliadin Induces Moderate Enteropathy and Insulitis in Nonobese Diabetic-DQ8 Mice  Journal Articles
• Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer  Journal Articles
• Sex-Dependent Differences in Spontaneous Autoimmunity in Adult 3xTg-AD Mice  Journal Articles
• Shedding a new light on Huntington’s disease: how blood can both propagate and ameliorate disease pathology  Journal Articles
• Single Unpurified Breast Tumor-Initiating Cells from Multiple Mouse Models Efficiently Elicit Tumors in Immune-Competent Hosts  Journal Articles
• Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK  Journal Articles
• Sleep of transgenic mice producing excess rat growth hormone  Journal Articles
• Smad7 alters cell fate decisions of human hematopoietic repopulating cells  Journal Articles
• Sodium channel distribution in axons of hypomyelinated and MAG null mutant mice  Journal Articles
• Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract  Journal Articles
• Specific CD45 isoforms differentially regulate T cell receptor signaling.  Journal Articles
• Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson’s Disease  Journal Articles
• Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis  Journal Articles
• Stimulatory and inhibitory signaling molecules that regulate renal branching morphogenesis  Journal Articles
• Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin  Journal Articles
• Stromal β-catenin overexpression contributes to the pathogenesis of renal dysplasia  Journal Articles
• Suppression of NK and CD8+ T cells reduces astrogliosis but accelerates cerebellar dysfunction and shortens life span in a mouse model of Sandhoff disease  Journal Articles
• Suppression of neuronal AMPKβ2 isoform impairs recognition memory and synaptic plasticity.  Journal Articles
• TDAG51 Is Induced by Homocysteine, Promotes Detachment-mediated Programmed Cell Death, and Contributes to the Development of Atherosclerosis in Hyperhomocysteinemia  Journal Articles
• TIM-4 Expressed by Mucosal Dendritic Cells Plays a Critical Role in Food Antigen–Specific Th2 Differentiation and Intestinal Allergy  Journal Articles
• Targeted Expression of Human CD1d in Transgenic Mice Reveals Independent Roles for Thymocytes and Thymic APCs in Positive and Negative Selection of Vα14i NKT Cells  Journal Articles
• Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction  Journal Articles
• Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease  Journal Articles
• Telomerase activity in normal and malignant murine tissues.  Journal Articles
• The AIDS Disease of CD4C/HIV Transgenic Mice Shows Impaired Germinal Centers and Autoantibodies and Develops in the Absence of IFN-γ and IL-6  Journal Articles
• The Absence or Overexpression of IL-15 Drastically Alters Breast Cancer Metastasis via Effects on NK Cells, CD4 T Cells, and Macrophages  Journal Articles
• The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways  Journal Articles
• The POZ-ZF Transcription Factor Kaiso (ZBTB33) Induces Inflammation and Progenitor Cell Differentiation in the Murine Intestine  Journal Articles
• The Pathophysiology of the Peritoneal Membrane  Journal Articles
• The Transcriptional Repressor ZEB Regulates p73 Expression at the Crossroad between Proliferation and Differentiation  Journal Articles
• The breast tumor microenvironment alters the phenotype and function of natural killer cells  Journal Articles
• The function of IGF-IR in NNK-mediated lung tumorigenesis  Journal Articles
• The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer  Journal Articles
• The human SCGB2A2 (Mammaglobin-1) promoter/enhancer in a helper-dependent adenovirus vector directs high levels of transgene expression in mammary carcinoma cells but not in normal nonmammary cells  Journal Articles
• The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis  Journal Articles
• The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism  Journal Articles
• The role of the type I insulin-like growth factor receptor (IGF-IR) in glomerular integrity  Journal Articles
• The serine protease inhibitor neuroserpin is required for normal synaptic plasticity and regulates learning and social behavior  Journal Articles
• The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism  Journal Articles
• Thrombus stability explains the factor V Leiden paradox: a mouse model  Journal Articles
• Thymic CD45 tyrosine phosphatase regulates apoptosis and MHC-restricted negative selection.  Journal Articles
• Tissue Factor and Thrombosis Models  Journal Articles
• Tissue factor microparticles and haemophilia  Journal Articles
• Tissue specificity of oncogene action: endothelial cell tumours in polyoma middle T transgenic mice.  Journal Articles
• Tissue- and site-specific DNA recombination in transgenic mice.  Journal Articles
• Toxicogenomic Analysis of Mainstream Tobacco Smoke-Exposed Mice Reveals Repression of Plasminogen Activator Inhibitor-1 Gene in Heart  Journal Articles
• Transgene-induced production of IL-4 alters the development and collagen expression of T helper cell 1-type pulmonary granulomas.  Journal Articles
• Transgenic expression of neuronal dystonin isoform 2 partially rescues the disease phenotype of the dystonia musculorum mouse model of hereditary sensory autonomic neuropathy VI.  Journal Articles
• Transgenic mice expressing the βAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination  Journal Articles
• Transgenic mice over-expressing substance P exhibit allodynia and hyperalgesia which are reversed by substance P and N-methyl-d-aspartate receptor antagonists  Journal Articles
• Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation  Journal Articles
• Transplants of neurosphere cell suspensions from aged mice are functional in the mouse model of Parkinson's  Journal Articles
• Treatment of hemophilia B in mice with nonautologous somatic gene therapeutics  Journal Articles
• Trophic and proliferative effects of Shh on motor neurons in embryonic spinal cord culture from wildtype and G93A SOD1 mice  Journal Articles
• Tumour therapy in mice using adenovirus vectors expressing human TNFa.  Journal Articles
• Type I Insulin-like Growth Factor Receptor Induces Pulmonary Tumorigenesis  Journal Articles
• Type I Interferon Receptor on NK Cells Negatively Regulates Interferon-γ Production  Journal Articles
• USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation  Journal Articles
• Update on pathways regulating the activation of uterine Natural Killer cells, their interactions with decidual spiral arteries and homing of their precursors to the uterus  Journal Articles
• Upregulation of an opioid-mediated antinociceptive mechanism in transgenic mice over-expressing substance P in the spinal cord  Journal Articles
• Uterine natural killer cells: insights into their cellular and molecular biology from mouse modelling  Journal Articles