Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract Journal Articles uri icon

  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All


  • The gonococcal Opa proteins are an antigenically variable family of surface adhesins that bind human carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), CEACAM3, CEACAM5, and/or CEACAM6, cell surface glycoproteins that are differentially expressed on a broad spectrum of human cells and tissues. While they are presumed to be important for infection, the significance of various Opa-CEACAM-mediated cellular interactions in the context of the genital tract has remained unclear.


  • Islam, Epshita A
  • Anipindi, Varun C
  • Francis, Ian
  • Shaik-Dasthagirisaheb, Yazdan
  • Xu, Stacey
  • Leung, Nelly
  • Sintsova, Anna
  • Amin, Mohsen
  • Kaushic, Charu
  • Wetzler, Lee M
  • Gray-Owen, Scott D

publication date

  • August 2018

has subject area