Journal article
Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract
Abstract
The gonococcal Opa proteins are an antigenically variable family of surface adhesins that bind human carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), CEACAM3, CEACAM5, and/or CEACAM6, cell surface glycoproteins that are differentially expressed on a broad spectrum of human cells and tissues. While they are presumed to be important for infection, the significance of various Opa-CEACAM-mediated cellular interactions in the …
Authors
Islam EA; Anipindi VC; Francis I; Shaik-Dasthagirisaheb Y; Xu S; Leung N; Sintsova A; Amin M; Kaushic C; Wetzler LM
Journal
Infection and Immunity, Vol. 86, No. 8, pp. 10.1128/iai.00092–10.1128/iai.00018
Publisher
American Society for Microbiology
Publication Date
August 2018
DOI
10.1128/iai.00092-18
ISSN
0019-9567
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntigens, CDBacterial AdhesionBacterial Outer Membrane ProteinsCarcinoembryonic AntigenCell Adhesion MoleculesDisease Models, AnimalEpithelial CellsFemaleGPI-Linked ProteinsGene Expression ProfilingGenitalia, FemaleGonorrheaHost-Pathogen InteractionsHumansImmunohistochemistryMice, Inbred C57BLMice, TransgenicNeisseria gonorrhoeaeReproductive Tract InfectionsTreatment OutcomeUterusVagina