Journal article
Tissue- and site-specific DNA recombination in transgenic mice.
Abstract
We have developed a method of specifically modifying the mammalian genome in vivo. This procedure comprises heritable tissue-specific and site-specific DNA recombination as a function of recombinase expression in transgenic mice. Transgenes encoding the bacteriophage P1 Cre recombinase and the loxP-flanked beta-galactosidase gene were used to generate transgenic mice. Genomic DNA from doubly transgenic mice exhibited tissue-specific DNA …
Authors
Orban PC; Chui D; Marth JD
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 15, pp. 6861–6865
Publisher
Proceedings of the National Academy of Sciences
Publication Date
8 1992
DOI
10.1073/pnas.89.15.6861
ISSN
0027-8424