Journal article
Targeted Expression of Human CD1d in Transgenic Mice Reveals Independent Roles for Thymocytes and Thymic APCs in Positive and Negative Selection of Vα14i NKT Cells
Abstract
CD1d-dependent invariant Valpha14 (Valpha14i) NKT cells are innate T lymphocytes expressing a conserved semi-invariant TCR, consisting, in mice, of the invariant Valpha14-Jalpha18 TCR alpha-chain paired mostly with Vbeta8.2 and Vbeta7. The cellular requirements for thymic positive and negative selection of Valpha14i NKT cells are only partially understood. Therefore, we generated transgenic mice expressing human CD1d (hCD1d) either on …
Authors
Schümann J; Pittoni P; Tonti E; MacDonald HR; Dellabona P; Casorati G
Journal
The Journal of Immunology, Vol. 175, No. 11, pp. 7303–7310
Publisher
Oxford University Press (OUP)
Publication Date
December 1, 2005
DOI
10.4049/jimmunol.175.11.7303
ISSN
0022-1767