ER Stress and Lipogenesis: A Slippery Slope toward Hepatic Steatosis Journal Articles

abstract

• Endoplasmic reticulum (ER) stress and activation of the unfolded protein response have been linked to many human disorders, including obesity, type 2 diabetes, and cancer. In this issue of Developmental Cell,Rutkowski et al. (2008) show that unresolved ER stress contributes to metabolic dysfunction and hepatic steatosis.

authors

• Basseri, Sana
• Austin, Richard C

status

• published 

publication date

• December 2008

has subject area

• 06 Biological Sciences (FoR)
• 11 Medical and Health Sciences (FoR)
• Animals (MeSH)
• Developmental Biology (Science Metrix)
• Endoplasmic Reticulum (MeSH)
• Fatty Acids (MeSH)
• Fatty Liver (MeSH)
• Humans (MeSH)
• Lipids (MeSH)
• Mice (MeSH)
• Mice, Transgenic (MeSH)
• Models, Biological (MeSH)
• Oxygen (MeSH)
• Protein Denaturation (MeSH)
• Protein Folding (MeSH)
• Triglycerides (MeSH)
• Up-Regulation (MeSH)

published in

• Developmental Cell  Journal

keywords

• Animals
• Endoplasmic Reticulum
• Fatty Acids
• Fatty Liver
• Humans
• Lipids
• Mice
• Mice, Transgenic
• Models, Biological
• Oxygen
• Protein Denaturation
• Protein Folding
• Triglycerides
• Up-Regulation

Digital Object Identifier (DOI)

• 10.1016/j.devcel.2008.11.013

PubMed ID

• 19081067

start page

• 795

end page

• 796

volume

• 15

issue

• 6