ER Stress and Lipogenesis: A Slippery Slope toward Hepatic Steatosis Academic Article uri icon

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abstract

  • Endoplasmic reticulum (ER) stress and activation of the unfolded protein response have been linked to many human disorders, including obesity, type 2 diabetes, and cancer. In this issue of Developmental Cell,Rutkowski et al. (2008) show that unresolved ER stress contributes to metabolic dysfunction and hepatic steatosis.

publication date

  • December 2008