Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection Journal Articles uri icon

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  • AbstractRecent studies have reported that COVID-19 patients with lung cancer have a higher risk of severe events than patients without cancer. In this study, we investigated the gene expression of angiotensin I-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) with prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Lung cancer patients in each age stage, subtype, and pathological stage are susceptible to SARS-CoV-2 infection, except for the primitive subtype of LUSC. LUAD patients are more susceptible to SARS-CoV-2 infection than LUSC patients. The findings are unanimous on tissue expression in gene and protein levels.


  • Kong, Qi
  • Xiang, Zhiguang
  • Wu, Yue
  • Gu, Yu
  • Guo, Jianguo
  • Geng, Fei

publication date

  • December 2020

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