Journal article
An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene
Abstract
Adenoviral (Ad)-mediated in vivo gene transfer and expression are limited in part by cellular immune responses to viral-encoded proteins and/or transgene immunogenicity. In an attempt to diminish the former responses, we have previously developed and described helper-dependent (HD) Ad vectors in which the viral protein coding sequences are completely eliminated. These HD vectors have up to 37 kb insert capacity, are easily propagated in a Cre …
Authors
Morsy MA; Gu M; Motzel S; Zhao J; Lin J; Su Q; Allen H; Franlin L; Parks RJ; Graham FL
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 14, pp. 7866–7871
Publisher
Proceedings of the National Academy of Sciences
Publication Date
July 7, 1998
DOI
10.1073/pnas.95.14.7866
ISSN
0027-8424