Journal article
Male Sexual Dysfunction in Mice Bearing Targeted Mutant Alleles of the PEA3 ets Gene
Abstract
PEA3, a member of the Ets family of transcriptional regulatory proteins, is expressed in a unique spatial and temporal pattern during mouse embryogenesis; its overexpression is positively correlated with HER2-mediated breast tumorigenesis in both humans and mice. To determine whether PEA3 plays a part in development and oncogenesis and to uncover its normal physiological role, we generated mice lacking functional PEA3 by gene targeting in …
Authors
Laing MA; Coonrod S; Hinton BT; Downie JW; Tozer R; Rudnicki MA; Hassell JA
Journal
Molecular and Cellular Biology, Vol. 20, No. 24, pp. 9337–9345
Publisher
Taylor & Francis
Publication Date
December 1, 2000
DOI
10.1128/mcb.20.24.9337-9345.2000
ISSN
0270-7306
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AcetylcholineAdrenergic alpha-AgonistsAnimalsBlotting, SouthernCell LineChimeraEmbryo, MammalianEpididymisFemaleFibroblastsGene TargetingGenitalia, MaleHumansIn Vitro TechniquesInfertility, MaleMaleMiceMice, TransgenicMutationPenile ErectionPenisPhenylephrineRNASpermatozoaStem CellsTestisTranscription Factors