The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism

The transcription factor CREB-H has been found to regulate the expression of a suite of genes in mice that are involved in triglyceride metabolism, according to a new study by Ann-Hwee Lee and her colleagues. They also find loss-of-function mutations in the human gene for CREB-H that are associated with highly elevated levels of triglycerides, suggesting a similar role for the protein in humans.