Journal article
Transgene-induced production of IL-4 alters the development and collagen expression of T helper cell 1-type pulmonary granulomas.
Abstract
A number of complex mechanisms regulate the size and cellularity of an Ag-dependent granulomatous reaction and their accompanying cytokine production profiles. In the present study, Th1 (purified protein derivative (PPD)) and Th2 (schistosome egg Ag)-type granulomas were established to examine the role of IL-4 in lesion development and procollagen type III expression. PPD-sensitized mice were transfected via the airway with an adenovirus …
Authors
Lukacs NW; Addison CL; Gauldie J; Graham F; Simpson K; Strieter RM; Warmington K; Chensue SW; Kunkel SL
Journal
The Journal of Immunology, Vol. 158, No. 9, pp. 4478–4484
Publisher
Oxford University Press (OUP)
Publication Date
May 1, 1997
DOI
10.4049/jimmunol.158.9.4478
ISSN
0022-1767