Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13 Journal Articles

abstract

• Key Points MN1 promotes self-renewal and inhibits differentiation of CD34+ cord blood cells in vitro. De novo leukemogenesis is engineered by MN1 and NUP98HOXD13 expression in cord blood cells.

authors

• Imren, Suzan
• Heuser, Michael
• Gasparetto, Maura
• Beer, Philip A
• Norddahl, Gudmundur L
• Xiang, Ping
• Chen, Ling
• Berg, Tobias
• Rhyasen, Garrett W
• Rosten, Patricia
• Park, Gyeongsin
• Moon, Yeonsook
• Weng, Andrew P
• Eaves, Connie J
• Humphries, R Keith

status

• published 

publication date

• December 4, 2014

has subject area

• 1102 Cardiorespiratory Medicine and Haematology (FoR)
• 1103 Clinical Sciences (FoR)
• 1114 Paediatrics and Reproductive Medicine (FoR)
• Animals (MeSH)
• Cell Transformation, Neoplastic (MeSH)
• Fetal Blood (MeSH)
• Humans (MeSH)
• Immunology (Science Metrix)
• Leukemia, Myeloid, Acute (MeSH)
• Mice, Inbred NOD (MeSH)
• Mice, SCID (MeSH)
• Mice, Transgenic (MeSH)
• Neoplasms, Experimental (MeSH)
• Oncogene Proteins, Fusion (MeSH)
• Trans-Activators (MeSH)
• Tumor Suppressor Proteins (MeSH)

published in

• Blood  Journal

keywords

• Animals
• Cell Transformation, Neoplastic
• Fetal Blood
• Humans
• Leukemia, Myeloid, Acute
• Mice, Inbred NOD
• Mice, SCID
• Mice, Transgenic
• Neoplasms, Experimental
• Oncogene Proteins, Fusion
• Trans-Activators
• Tumor Suppressor Proteins

Digital Object Identifier (DOI)

• 10.1182/blood-2014-04-564666

start page

• 3608

end page

• 3612

volume

• 124

issue

• 24