Journal article
Increased Bacterial Translocation in Gluten-Sensitive Mice Is Independent of Small Intestinal Paracellular Permeability Defect
Abstract
AimWe investigated whether treatment with gliadin induces a paracellular permeability defect that enhances bacterial translocation to mesenteric lymph nodes (MLN) via resident dendritic cells (DC) expressing TLR-2 or 4 in HCD4/HLA-DQ8 transgenic mice.MethodsHLA-DQ8 transgenic mice were sensitized and subsequently gavaged with gliadin, in the presence or absence of AT1001 (paracellular permeability inhibitor). Non-sensitized mice were gavaged …
Authors
Silva MA; Jury J; Sanz Y; Wiepjes M; Huang X; Murray JA; David CS; Fasano A; Verdú EF
Journal
Digestive Diseases and Sciences, Vol. 57, No. 1, pp. 38–47
Publisher
Springer Nature
Publication Date
1 2012
DOI
10.1007/s10620-011-1847-z
ISSN
0163-2116