Journal article
The function of IGF-IR in NNK-mediated lung tumorigenesis
Abstract
The type I insulin-like growth factor receptor (IGF-IR) is associated with many different types of cancer and it has been found to be involved in many aspects of the malignant phenotype, such as mitogenesis, survival, transformation and metastasis. This receptor has been observed to be overexpressed in the majority of lung cancer cell lines and human lung tumor biopsies. Two doxycycline-inducible transgenic mouse models in which the human …
Authors
Siwicky MD; Petrik JJ; Moorehead RA
Journal
Lung Cancer, Vol. 71, No. 1, pp. 11–18
Publisher
Elsevier
Publication Date
1 2011
DOI
10.1016/j.lungcan.2010.03.012
ISSN
0169-5002