Journal article
The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer
Abstract
A comprehensive differential gene expression screen on a panel of 54 breast tumors and >200 normal tissue samples using DNA microarrays revealed 15 genes specifically overexpressed in breast cancer. One of the most prevalent genes found was trichorhinophalangeal syndrome type 1 (TRPS-1), a gene previously shown to be associated with three rare autosomal dominant genetic disorders known as the trichorhinophalangeal syndromes. A number of …
Authors
Radvanyi L; Singh-Sandhu D; Gallichan S; Lovitt C; Pedyczak A; Mallo G; Gish K; Kwok K; Hanna W; Zubovits J
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 31, pp. 11005–11010
Publisher
Proceedings of the National Academy of Sciences
Publication Date
August 2, 2005
DOI
10.1073/pnas.0500904102
ISSN
0027-8424
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceAnimalsAntigens, NeoplasmBreast NeoplasmsCell Line, TumorDNA, NeoplasmDNA-Binding ProteinsEpitopesFemaleGene Expression ProfilingHumansImmunohistochemistryLanger-Giedion SyndromeMiceMice, TransgenicMolecular Sequence DataNeoplasm ProteinsOligonucleotide Array Sequence AnalysisRNA, MessengerRNA, NeoplasmRepressor ProteinsT-LymphocytesTranscription Factors