Journal article
Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection
Abstract
BackgroundOsteopontin (OPN) as a secreted signaling protein is dramatically induced in response to cellular injury and neurodegeneration. Microglial inflammatory responses in the brain are tightly associated with the neuropathologic hallmarks of neurodegenerative disease, but understanding of the molecular mechanisms remains in several contexts poorly understood.MethodsMicro-positron emission tomography (PET) neuroimaging using radioligands to …
Authors
Mahmud FJ; Du Y; Greif E; Boucher T; Dannals RF; Mathews WB; Pomper MG; Sysa-Shah P; Metcalf Pate KA; Lyons C
Journal
Journal of Neuroinflammation, Vol. 17, No. 1,
Publisher
Springer Nature
Publication Date
December 2020
DOI
10.1186/s12974-020-01949-4
ISSN
1742-2094