Journal article
The role of the type I insulin-like growth factor receptor (IGF-IR) in glomerular integrity
Abstract
Insulin-like growth factors (IGFs) have been implicated in normal mammalian kidney development. To confirm a role for the IGF system in podocyte and glomerular integrity, we generated a transgenic mouse that expresses a dominant-negative type 1 IGF receptor (IGF-IR) and determined the structural and functional consequences. Using a 4.25kb fragment of the murine nephrin promoter, the dominant-negative construct was expressed exclusively in the …
Authors
Bridgewater DJ; Dionne JM; Butt MJ; Pin CL; Matsell DG
Journal
Growth Hormone & IGF Research, Vol. 18, No. 1, pp. 26–37
Publisher
Elsevier
Publication Date
February 2008
DOI
10.1016/j.ghir.2007.06.003
ISSN
1096-6374