Journal article
The Transcriptional Repressor ZEB Regulates p73 Expression at the Crossroad between Proliferation and Differentiation
Abstract
The newly discovered p73 gene encodes a nuclear protein that has high homology with p53. Furthermore, ectopic expression of p73 in p53(+/+) and p53(-/-) cancer cells recapitulates some of the biological activities of p53 such as growth arrest, apoptosis, and differentiation. p73(-/-)-deficient mice exhibit severe defects in proper development of the central nervous system and pheromone sensory pathway. They also suffer from inflammation and …
Authors
Fontemaggi G; Gurtner A; Strano S; Higashi Y; Sacchi A; Piaggio G; Blandino G
Journal
Molecular and Cellular Biology, Vol. 21, No. 24, pp. 8461–8470
Publisher
Taylor & Francis
Publication Date
December 1, 2001
DOI
10.1128/mcb.21.24.8461-8470.2001
ISSN
0270-7306
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisBase SequenceBinding SitesBlotting, WesternCell DifferentiationCell DivisionCell LineCell NucleusCells, CulturedChromatinCloning, MolecularCodonDNA-Binding ProteinsExonsGenes, DominantGenes, ReporterGenes, Tumor SuppressorHL-60 CellsHomeodomain ProteinsHumansIntronsLuciferasesMiceMice, TransgenicModels, GeneticMolecular Sequence DataMutagenesis, Site-DirectedNuclear ProteinsPrecipitin TestsPromoter Regions, GeneticProtein BindingProtein IsoformsRNA, MessengerRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionTetradecanoylphorbol AcetateTranscription FactorsTranscription, GeneticTransfectionTumor Protein p73Tumor Suppressor ProteinsZinc Finger E-box-Binding Homeobox 1