Thrombus stability explains the factor V Leiden paradox: a mouse model Journal Articles

abstract

• Key Points FVL homozygous mice have increased thrombus size and reduced pulmonary embolism burden compared with WT mice. FVL carriers develop more stable thrombi, which become clinical deep vein thrombosis more often than noncarriers, explaining the FVL paradox.

authors

• Shaya, SA
• Westrick, RJ
• Gross, Peter Lawrence

status

• published 

publication date

• November 12, 2019

has subject area

• Animals (MeSH)
• Biomarkers (MeSH)
• Biopsy (MeSH)
• Blood Coagulation (MeSH)
• Blood Coagulation Tests (MeSH)
• Disease Models, Animal (MeSH)
• Factor V (MeSH)
• Genetic Association Studies (MeSH)
• Genetic Predisposition to Disease (MeSH)
• Humans (MeSH)
• Immunohistochemistry (MeSH)
• Mice (MeSH)
• Mice, Transgenic (MeSH)
• Venous Thrombosis (MeSH)

published in

• Blood Advances  Journal

keywords

• Animals
• Biomarkers
• Biopsy
• Blood Coagulation
• Blood Coagulation Tests
• Disease Models, Animal
• Factor V
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Immunohistochemistry
• Mice
• Mice, Transgenic
• Venous Thrombosis

Digital Object Identifier (DOI)

• 10.1182/bloodadvances.2019031112

start page

• 3375

end page

• 3378

volume

• 3

issue

• 21