Journal article
Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer
Abstract
Human breast tumors comprise a minor sub-population of tumor-initiating cells (TICs), commonly termed cancer stem cells. TICs are thought to sustain tumor growth and to confer resistance to current anticancer therapies. Hence, targeting TIC may be essential to achieving durable cancer cures. To identify molecular targets in breast TIC, we employed a transgenic mouse model of ERBB2 breast cancer; tumors arising in this model comprise a very high …
Authors
Kondratyev M; Kreso A; Hallett RM; Girgis-Gabardo A; Barcelon ME; Ilieva D; Ware C; Majumder PK; Hassell JA
Journal
Oncogene, Vol. 31, No. 1, pp. 93–103
Publisher
Springer Nature
Publication Date
January 5, 2012
DOI
10.1038/onc.2011.212
ISSN
0950-9232