Journal article
Reduced Tissue Levels of Noradrenaline Are Associated with Behavioral Phenotypes of the TgCRND8 Mouse Model of Alzheimer's Disease
Abstract
Noradrenergic cell loss is well documented in Alzheimer's disease (AD). We have measured the tissue levels of catecholamines in an amyloid precursor protein-transgenic ‘TgCRND8’ mouse model of AD and found reductions in noradrenaline (NA) within hippocampus, temporoparietal and frontal cortices, and cerebellum. An age-related increase in cortical NA levels was observed in non-Tg controls, but not in TgCRND8 mice. In contrast, NA levels declined …
Authors
Francis BM; Yang J; Hajderi E; Brown ME; Michalski B; McLaurin J; Fahnestock M; Mount HTJ
Journal
Neuropsychopharmacology, Vol. 37, No. 8, pp. 1934–1944
Publisher
Springer Nature
Publication Date
7 2012
DOI
10.1038/npp.2012.40
ISSN
0893-133X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adrenergic Uptake InhibitorsAdrenergic alpha-2 Receptor AntagonistsAgingAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBenzopyransBrainBrain-Derived Neurotrophic FactorCatecholaminesCholinesterase InhibitorsDesipramineDisease Models, AnimalImidazolesImmobility Response, TonicMiceMice, Inbred C57BLMice, TransgenicPhenylcarbamatesRecognition, PsychologyRivastigmine