Journal article
Characterization of a Mouse Model for Thrombomodulin Deficiency
Abstract
Mutations in the gene encoding thrombomodulin (TM), a thrombin regulator, are suspected risk factors for venous and arterial thrombotic disease. We have previously described the generation of TM(Pro/Pro) mice carrying a TM gene mutation that disrupts the TM-dependent activation of protein C. Here, it is shown that inbred C57BL/6J TM(Pro/Pro) mice exhibit a hypercoagulable state and an increased susceptibility to thrombosis and sepsis. Platelet …
Authors
Weiler H; Lindner V; Kerlin B; Isermann BH; Hendrickson SB; Cooley BC; Meh DA; Mosesson MW; Shworak NW; Post MJ
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 21, No. 9, pp. 1531–1537
Publisher
Wolters Kluwer
Publication Date
9 2001
DOI
10.1161/hq0901.094496
ISSN
1079-5642