Journal article
Object recognition memory and BDNF expression are reduced in young TgCRND8 mice
Abstract
The TgCRND8 mouse model of Alzheimer's disease exhibits progressive cortical and hippocampal β-amyloid accumulation, resulting in plaque pathology and spatial memory impairment by 3 months of age. We tested whether TgCRND8 cognitive function is disrupted prior to the appearance of macroscopic plaques in an object recognition task. We found profound deficits in 8-week-old mice. Animals this age were not impaired on the Morris water maze task. …
Authors
Francis BM; Kim J; Barakat ME; Fraenkl S; Yücel YH; Peng S; Michalski B; Fahnestock M; McLaurin J; Mount HTJ
Journal
Neurobiology of Aging, Vol. 33, No. 3, pp. 555–563
Publisher
Elsevier
Publication Date
March 2012
DOI
10.1016/j.neurobiolaging.2010.04.003
ISSN
0197-4580