Journal article
CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control
Abstract
During the course of biological aging, there is a gradual accumulation of damaged proteins and a concomitant functional decline in the protein degradation system. Protein quality control is normally ensured by the coordinated actions of molecular chaperones and the protein degradation system that collectively help to maintain protein homeostasis. The carboxyl terminus of Hsp70-interacting protein (CHIP), a ubiquitin ligase/cochaperone, …
Authors
Min J-N; Whaley RA; Sharpless NE; Lockyer P; Portbury AL; Patterson C
Journal
Molecular and Cellular Biology, Vol. 28, No. 12, pp. 4018–4025
Publisher
Taylor & Francis
Publication Date
June 1, 2008
DOI
10.1128/mcb.00296-08
ISSN
0270-7306