Journal article
The POZ-ZF Transcription Factor Kaiso (ZBTB33) Induces Inflammation and Progenitor Cell Differentiation in the Murine Intestine
Abstract
Since its discovery, several studies have implicated the POZ-ZF protein Kaiso in both developmental and tumorigenic processes. However, most of the information regarding Kaiso's function to date has been gleaned from studies in Xenopus laevis embryos and mammalian cultured cells. To examine Kaiso's role in a relevant, mammalian organ-specific context, we generated and characterized a Kaiso transgenic mouse expressing a murine Kaiso transgene …
Authors
Chaudhary R; Pierre CC; Nanan K; Wojtal D; Morone S; Pinelli C; Wood GA; Robine S; Daniel JM
Journal
PLOS ONE, Vol. 8, No. 9,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0074160
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBasic Helix-Loop-Helix Transcription FactorsCateninsCell DifferentiationCell ProliferationEnterocytesFounder EffectGene Expression RegulationGoblet CellsHomeodomain ProteinsInflammationMiceMice, TransgenicMicrofilament ProteinsNeutrophil InfiltrationPaneth CellsPromoter Regions, GeneticReceptors, NotchSignal TransductionStem CellsTranscription Factor HES-1Transcription FactorsTransgenesDelta Catenin