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Hsp72 preserves muscle function and slows...
Journal article

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

Abstract

Increasing the expression of intramuscular heat shock protein 72 preserves muscle strength and ameliorates the dystrophic pathology in two mouse models of muscular dystrophy, suggesting a promising way forward for the treatment of muscular dystrophy.

Authors

Gehrig SM; van der Poel C; Sayer TA; Schertzer JD; Henstridge DC; Church JE; Lamon S; Russell AP; Davies KE; Febbraio MA

Journal

Nature, Vol. 484, No. 7394, pp. 394–398

Publisher

Springer Nature

Publication Date

April 19, 2012

DOI

10.1038/nature10980

ISSN

0028-0836

Associated Experts

Jonathan Schertzer

Professor, Faculty of Health Sciences
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Labels

Fields of Research (FoR)

3208 Medical Physiology32 Biomedical and Clinical Sciences

Medical Subject Headings (MeSH)

AnimalsCalcium-Transporting ATPasesDiaphragmDisease Models, AnimalDisease ProgressionFemaleGene Expression RegulationHSP72 Heat-Shock ProteinsKyphosisLongevityMaleMiceMice, Inbred mdxMice, TransgenicMuscle, SkeletalMuscular Dystrophy, DuchenneOximesPiperidinesRats
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