Journal article
Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia.
Abstract
We have used an insulin-like growth factor (IGF)-II transgenic mouse model in which mouse IGF-II is widely overexpressed, resulting in increased fetal size and selective organ overgrowth, to investigate the effects on the development of the endocrine pancreas. Fetuses examined on day 19.5-20 of gestation had significantly elevated circulating levels of IGF-II, compared with control mice. The pancreatic islets in transgenic animals were of …
Authors
Petrik J; Pell JM; Arany E; McDonald TJ; Dean WL; Reik W; Hill DJ
Journal
Endocrinology, Vol. 140, No. 5, pp. 2353–2363
Publisher
The Endocrine Society
Publication Date
May 1, 1999
DOI
10.1210/endo.140.5.6732
ISSN
0013-7227
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisGene ExpressionHyperplasiaIn Situ HybridizationInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 2Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IIIslets of LangerhansMiceMice, Inbred C57BLMice, Inbred CBAMice, TransgenicProliferating Cell Nuclear AntigenRNA, Messenger