Journal article
Reversibility and recurrence of IGF-IR-induced mammary tumors
Abstract
The type-I insulin-like growth factor receptor (IGF-IR) is frequently overexpressed in breast cancer and therapeutic agents targeting IGF-IR are currently in development. The ultimate success of anti-IGF-IR therapies will depend on the extent to which established tumors remain dependent upon IGF-IR signaling for sustained growth. To investigate the potential benefits and pitfalls of targeting IGF-IR, we used a doxycycline inducible mouse model …
Authors
Jones RA; Campbell CI; Wood GA; Petrik JJ; Moorehead RA
Journal
Oncogene, Vol. 28, No. 21, pp. 2152–2162
Publisher
Springer Nature
Publication Date
May 28, 2009
DOI
10.1038/onc.2009.79
ISSN
0950-9232