A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis Journal Articles

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abstract

Key Points A functional demonstration of the oncogenic role of mutated EZH2 in a mouse model is presented. The global effects of mutated EZH2 on expression and epigenome have been characterized.

authors

Berg, Tobias
Thoene, Silvia
Yap, Damian
Wee, Tracee
Schoeler, Nathalie
Rosten, Patty
Lim, Emilia
Bilenky, Misha
Mungall, Andrew J
Oellerich, Thomas
Lee, Sherry
Lai, Courteney K
Umlandt, Patricia
Salmi, Anisa
Chang, Harry
Yue, Lisa
Lai, David
Cheng, S-W Grace
Morin, Ryan D
Hirst, Martin
Serve, Hubert
Marra, Marco A
Morin, Gregg B
Gascoyne, Randy D
Aparicio, Samuel A
Humphries, R Keith

status

published

publication date

June 19, 2014

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Animals (MeSH)
B-Lymphocytes (MeSH)
Blotting, Western (MeSH)
Bone Marrow Cells (MeSH)
Cell Proliferation (MeSH)
Cell Transformation, Neoplastic (MeSH)
Disease Models, Animal (MeSH)
Female (MeSH)
Flow Cytometry (MeSH)
Gene Expression Profiling (MeSH)
Histones (MeSH)
Humans (MeSH)
Immunology (Science Metrix)
Kaplan-Meier Estimate (MeSH)
Lymphoma (MeSH)
Lymphoma, B-Cell (MeSH)
Lysine (MeSH)
Male (MeSH)
Methylation (MeSH)
Mice (MeSH)
Mice, Inbred C57BL (MeSH)
Mice, Transgenic (MeSH)
Mutation (MeSH)
Polycomb Repressive Complex 2 (MeSH)
Proto-Oncogene Proteins c-myc (MeSH)
Spleen (MeSH)

published in

Blood Journal