Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis Journal Articles

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abstract

Key PointsMutation of the PC-binding domain of EPCR results in viable mice that exhibit procoagulant and proinflammatory phenotype when challenged. EPCRR84A/R84A mice develop splenomegaly as a result of BM failure, suggesting that EPCR plays an important role in hematopoiesis.

authors

Pepler, Laura
Yu, Pei
Dwivedi, Dhruva J
Trigatti, Bernardo
Liaw, Patricia Chia-Ying

status

published

publication date

July 30, 2015

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Amino Acid Substitution (MeSH)
Animals (MeSH)
Antithrombin III (MeSH)
Bone Marrow Transplantation (MeSH)
Cell Line (MeSH)
Endothelial Protein C Receptor (MeSH)
Female (MeSH)
Hematopoiesis (MeSH)
Immunology (Science Metrix)
Inflammation (MeSH)
Male (MeSH)
Mice (MeSH)
Mice, Inbred C57BL (MeSH)
Mice, Mutant Strains (MeSH)
Mice, Transgenic (MeSH)
Mutagenesis, Site-Directed (MeSH)
Mutant Proteins (MeSH)
Peptide Hydrolases (MeSH)
Protein Binding (MeSH)
Protein C (MeSH)
Protein Interaction Domains and Motifs (MeSH)
Receptors, Cell Surface (MeSH)
Splenomegaly (MeSH)
Thrombosis (MeSH)

published in

Blood Journal