Enzyme Inhibitors Concept

subject area of

• 1,25-Dihydroxyvitamin D3Primes Acute Promyelocytic Cells for TPA-Induced Monocytic Differentiation through Both PKC and Tyrosine Phosphorylation Cascades  Journal Articles
• Campylobacter jejuni KDO8P Synthase, Its Inhibition by KDO8P Oxime, and Control of the Residence Time of Slow-Binding Inhibition  Journal Articles
• L‐NAME inhibits Mg²⁺‐induced rat aortic relaxation in the absence of endothelium  Journal Articles
• A Canadian Clinical Practice Algorithm for the Management of Patients with Non-Variceal Upper Gastrointestinal Bleeding  Journal Articles
• A Double-Blind, Randomized, Placebo-Controlled 4-Week Study on the Efficacy and Safety of the Purinergic Agents Allopurinol and Dipyridamole Adjunctive to Lithium in Acute Bipolar Mania  Journal Articles
• A Guided Materials Screening Approach for Developing Quantitative Sol-gel Derived Protein Microarrays  Journal Articles
• A New Target for Antibiotic Development  Journal Articles
• A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells  Journal Articles
• A Phase I Open-Label Dose-Escalation Study of Intravenous BI 2536 Together With Pemetrexed in Previously Treated Patients With Non–Small-Cell Lung Cancer  Journal Articles
• A Revisitation on the Mechanism of Action of KCI-lnduced Vascular Smooth Muscle Contraction: A Key Role of Cation Binding to the Plasma Membrane  Journal Articles
• A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions  Journal Articles
• A matrix-assisted laser desorption/ionization tandem mass spectrometry method for direct screening of small molecule mixtures against an aminoglycoside kinase  Journal Articles
• A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients.  Journal Articles
• A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia  Journal Articles
• A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors  Journal Articles
• A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment.  Journal Articles
• AEG3482 Is an Antiapoptotic Compound that Inhibits Jun Kinase Activity and Cell Death through Induced Expression of Heat Shock Protein 70  Journal Articles
• AMP-Activated Protein Kinase-Regulated Activation of the PGC-1α Promoter in Skeletal Muscle Cells  Journal Articles
• AMPK‐independent pathways regulate skeletal muscle fatty acid oxidation  Journal Articles
• Acid–base responses to feeding and intestinal Cl– uptake in freshwater- and seawater-acclimated killifish,Fundulus heteroclitus, an agastric euryhaline teleost  Journal Articles
• Activation of p38 mitogen-activated protein kinase during normal mitosis in the developing retina  Journal Articles
• Active site labeling of the gentamicin resistance enzyme AAC(6')-APH(2") by the lipid kinase inhibitor wortmannin  Journal Articles
• Adenosine‐AMP exchange activity is an integral part of the mammalian adenosine kinase  Journal Articles
• Akt Is Activated in Response to an Apoptotic Signal  Journal Articles
• American Society of Clinical Oncology Technology Assessment Working Group Update: Use of Aromatase Inhibitors in the Adjuvant Setting  Journal Articles
• American Society of Clinical Oncology Technology Assessment on the Use of Aromatase Inhibitors as Adjuvant Therapy for Women With Hormone Receptor–Positive Breast Cancer: Status Report 2002  Journal Articles
• Aminoglycoside-modifying enzymes  Journal Articles
• An Expedient and Facile One-Step Synthesis of a Biguanide Library by Microwave Irradiation Coupled with Simple Product Filtration. Inhibitors of Dihydrofolate Reductase  Journal Articles
• An In Vitro Screen of Bacterial Lipopolysaccharide Biosynthetic Enzymes Identifies an Inhibitor of ADP-Heptose Biosynthesis  Journal Articles
• An NMR based phosphodiesterase assay  Journal Articles
• An integrative, in situ approach to examining K⁺ flux in resting skeletal muscle  Journal Articles
• An integrative, in situ approach to examining K⁺ flux in resting skeletal muscle  Journal Articles
• Analysis of the interactions between an enzyme and multiple inhibitors using combination plots  Journal Articles
• Anemia management in chronic kidney disease and dialysis  Journal Articles
• Angiotensin II activates a nitric-oxide-driven inhibitory feedback in the rat paraventricular nucleus.  Journal Articles
• Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase  Journal Articles
• Antibiotic Resistance by Enzyme Inactivation: From Mechanisms to Solutions  Journal Articles
• Antioxidant responses and oxidative stress after microcystin exposure in the hepatopancreas of an estuarine crab species  Journal Articles
• Apocynum venetum leaf aqueous extract inhibits voltage-gated sodium channels of mouse neuroblastoma N2A cells  Journal Articles
• Apoptotic Release of Histones from Nucleosomes  Journal Articles
• Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria  Journal Articles
• Assessment of the downstream portion of the mitochondrial pathway of caspase activation in patients with acute myeloid leukemia  Journal Articles
• Autocrine VEGF‐A/KDR loop protects epithelial ovarian carcinoma cells from anoikis  Journal Articles
• BF061, a novel antiplatelet and antithrombotic agent targeting P2Y12 receptor and phosphodiesterase  Journal Articles
• BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38− cells, through activation of protein kinase Cβ  Journal Articles
• Binding of Anti-GRP78 Autoantibodies to Cell Surface GRP78 Increases Tissue Factor Procoagulant Activity via the Release of Calcium from Endoplasmic Reticulum Stores  Journal Articles
• Bleomycin-Induced Lung Toxicity and Pentoxifylline  Journal Articles
• Ca²⁺-dependent K⁺channels and Na⁺-K⁺-ATPase mediate H₂O₂- and superoxide-induced relaxations in canine trachealis  Journal Articles
• Calcium antagonistic actions of tetrandrine depend on cell types.  Journal Articles
• Calyculin A-induced endothelial cell shape changes are independent of [Ca2+]i elevation and may involve actin polymerization  Journal Articles
• Carbon monoxide formation in the ductus arteriosus in the lamb: implications for the regulation of muscle tone  Journal Articles
• Carbon monoxide‐induced relaxation of the ductus arteriosus in the lamb: evidence against the prime role of guanylyl cyclase  Journal Articles
• Cardiac Sarcomeric Proteins: Novel Intracellular Targets of Matrix Metalloproteinase-2 in Heart Disease  Journal Articles
• Case 216: Hypertrophic Spinal Pachymeningitis  Journal Articles
• Catalase activity in coronary artery endothelium protects smooth muscle against peroxide damage  Journal Articles
• Characterization of Cereulide Synthetase, a Toxin-Producing Macromolecular Machine  Journal Articles
• Characterization of two members of a novel malic enzyme class  Journal Articles
• Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane  Journal Articles
• Chemical biology of tetracycline antibioticsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.  Journal Articles
• Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology  Journal Articles
• Chronic Nicotine Blunts Hypoxic Sensitivity in Perinatal Rat Adrenal Chromaffin Cells via Upregulation of K_ATPChannels: Role of α7 Nicotinic Acetylcholine Receptor and Hypoxia-Inducible Factor-2α  Journal Articles
• Chronic opioids regulate K_ATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A  Journal Articles
• Clinically relevant concentrations of valproic acid modulate melatonin MT1 receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells  Journal Articles
• Combination plots as graphical tools in the study of enzyme inhibition  Journal Articles
• Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21WAF1/CIP1 and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity  Journal Articles
• Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions  Journal Articles
• Control of Motoneuron Survival by Angiogenin  Journal Articles
• Cooperation in signal transduction of extracellular guanosine 5′ triphosphate and nerve growth factor in neuronal differentiation of PC12 cells  Journal Articles
• Copper effects on key metabolic enzymes and mitochondrial membrane potential in gills of the estuarine crab Neohelice granulata at different salinities  Journal Articles
• Coronary artery wall shear stress is associated with endothelial dysfunction and expansive arterial remodelling in patients with coronary artery disease  Journal Articles
• Cost-Effectiveness and Cost-Utility of Long-Term Management Strategies for Heartburn  Journal Articles
• Covalently linking heparin to antithrombin enhances prothrombinase inhibition on activated platelets  Journal Articles
• Crosstalk between Notch and Sonic hedgehog signaling in a mouse model of amyotrophic lateral sclerosis  Journal Articles
• Curcumin prevents haloperidol‐induced development of abnormal oro‐facial movements: Possible implications of Bcl‐XL in its mechanism of action  Journal Articles
• Cyclopiazonic acid and thapsigargin induce platelet aggregation resulting from Ca2+ influx through Ca2+ store-activated Ca2+- channels  Journal Articles
• Cyclopiazonic acid, inhibiting the endoplasmic reticulum calcium pump, reduces the canine colonic pacemaker frequency.  Journal Articles
• Cystathionine β-Lyase Is Important for Virulence of Salmonella enterica Serovar Typhimurium  Journal Articles
• Cytochrome P450 3A4 Inhibitory Activity Studies within the Lycorine series of Alkaloids  Journal Articles
• Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis  Journal Articles
• DNA methyltransferase inhibitors—state of the art  Journal Articles
• Deficiency of intramuscular ICC increases fundic muscle excitability but does not impede nitrergic innervation  Journal Articles
• Demonstration in vitro of two intracellular inactivators of nitrate reductase from Neurospora  Journal Articles
• Determination of 4‐hydroxyproline‐2‐epimerase activity by capillary electrophoresis: A stereoselective platform for inhibitor screening of amino acid isomerases  Journal Articles
• Determination of the molecular states of the processive endocellulase Thermobifida fusca Cel9A during crystalline cellulose depolymerization  Journal Articles
• Development of New Deoxycytidine Kinase Inhibitors and Noninvasive in Vivo Evaluation Using Positron Emission Tomography  Journal Articles
• Development of a continuous assay for the measurement of tissue factor procoagulant activity on intact cells  Journal Articles
• Development, implementation, and evaluation of a ketoconazole practice guideline for ARDS prophylaxis  Journal Articles
• Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration  Journal Articles
• Direct Thrombin Inhibitors in Acute Coronary Syndromes  Journal Articles
• Duration of effect of lansoprazole on gastric pH and acid secretion in normal male volunteers  Journal Articles
• EGFR-PLCγ1 signaling mediates high glucose-induced PKCβ1-Akt activation and collagen I upregulation in mesangial cells  Journal Articles
• ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function  Journal Articles
• ETV5 as a regulator of matrix metalloproteinase 2 in human chondrosarcoma  Journal Articles
• Effect of Atrial Fibrillation on Atrial Thrombogenesis in Humans: Impact of Rate and Rhythm  Journal Articles
• Effect of Omeprazole on Regional and Temporal Variations in Intragastric Acidity  Journal Articles
• Effect of Th1 cytokines on acid secretion in pharmacologically characterised mouse gastric glands  Journal Articles
• Effect of delivery of MMP inhibitors from PDMS as a model IOL material on PCO markers  Journal Articles
• Effect of surgeon on outcome of antireflux surgery  Conferences
• Effects of Cytochrome P450 Inhibitors on the Biotransformation of Fluorogenic Substrates by Adult Male Rat Liver Microsomes and cDNA-Expressed Rat Cytochrome P450 Isoforms  Journal Articles
• Effects of cortisol and oestradiol on hepatic 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor proteins in late-gestation sheep fetus  Journal Articles
• Effects of geldanamycin on HIF-1α mediated angiogenesis and invasion in prostate cancer cells  Journal Articles
• Effects of methyl parathion on Chasmagnathus granulatus hepatopancreas: Protective role of Sesamol  Journal Articles
• Effects of peroxynitrite on pig coronary artery smooth muscle  Journal Articles
• Effects of peroxynitrite on sarcoplasmic reticulum Ca²⁺ pump in pig coronary artery smooth muscle  Journal Articles
• Effects of some isoprostanes on the human umbilical artery in vitro  Journal Articles
• Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension  Journal Articles
• Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis  Journal Articles
• Efficacy and safety of nintedanib in patients with advanced idiopathic pulmonary fibrosis  Journal Articles
• Eliminating Competition: Characterizing and Eliminating Competitive Binding at Separate Sites between DAHP Synthase’s Essential Metal Ion and the Inhibitor DAHP Oxime  Journal Articles
• Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3β Activation in Apolipoprotein E–Deficient Mouse Models of Accelerated Atherosclerosis  Journal Articles
• Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2  Journal Articles
• Endothelial NOS, estrogen receptor β, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer  Journal Articles
• Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase  Journal Articles
• Epigenetic induction of melatonin MT 1 receptors by valproate: Neurotherapeutic implications  Journal Articles
• Esomeprazole 20 mg vs. pantoprazole 20 mg for maintenance therapy of healed erosive oesophagitis: results from the EXPO study¹  Journal Articles
• Estrogen Receptor-α and Endothelial Nitric Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase  Journal Articles
• Etiology of Dyspepsia: Implication for Empiric Therapy  Journal Articles
• Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds  Journal Articles
• Expression of p27 in Residual Rectal Cancer after Preoperative Chemoradiation Predicts Long-term Outcome  Journal Articles
• Expression of tissue-type transglutaminase (tTG) and the effect of tTG inhibitor on the hippocampal CA1 region after transient ischemia in gerbils  Journal Articles
• Extracellular guanosine 5′ triphosphate enhances nerve growth factor-induced neurite outgrowth via increases in intracellular calcium  Journal Articles
• Fc-γ Receptor Cross-Linking by Immune Complexes Induces Matrix Metalloproteinase-1 in U937 Cells via Mitogen-Activated Protein Kinase  Conferences
• Finasteride-Induced Myalgia and HyperCKemia  Journal Articles
• First Data on Efficacy and Safety of Nintedanib in Patients with Idiopathic Pulmonary Fibrosis and Forced Vital Capacity of ≤50 % of Predicted Value  Journal Articles
• GERD 2003 – A Consensus on the Way Ahead  Journal Articles
• Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer  Journal Articles
• Gatekeeping versus Promiscuity in the Early Stages of the Andrimid Biosynthetic Assembly Line  Journal Articles
• Generation of slow waves in membrane potential is an intrinsic property of interstitial cells of Cajal  Journal Articles
• Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity  Journal Articles
• Giardia lamblia RNA Polymerase II  Journal Articles
• Glucosamine induces ER stress by disrupting lipid-linked oligosaccharide biosynthesis andN-linked protein glycosylation  Journal Articles
• Glucose transporter expression in L6 muscle cells: Regulation through insulin- and stress-activated pathways  Journal Articles
• Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation  Journal Articles
• Guanosine protects SH-SY5Y cells against β-amyloid-induced apoptosis  Journal Articles
• Heparin Synergistically Enhances Interleukin-11 Signaling through Up-regulation of the MAPK Pathway  Journal Articles
• Heteroactivation of cytochrome P450 1A1 by teas and tea polyphenols  Journal Articles
• High quality drug screening by capillary electrophoresis: A review  Journal Articles
• High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones  Journal Articles
• Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid  Journal Articles
• Hydrogen peroxide induces a greater contraction in mesenteric arteries of spontaneously hypertensive rats through thromboxane A₂ production  Journal Articles
• Identification and Biochemical Studies on Novel Non-Nucleoside Inhibitors of the Enzyme Adenosine Kinase  Journal Articles
• Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase  Journal Articles
• Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells  Journal Articles
• Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β‐Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry  Journal Articles
• Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity  Journal Articles
• Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation  Journal Articles
• Impairment of pyruvate dehydrogenase activity by acetaldehyde  Journal Articles
• Implication of a Nitric Oxide Synthase Mechanism in the Action of Substance P: L‐NAME Blocks Thermal Hyperalgesia Induced by Endogenous and Exogenous Substance P in the Rat  Journal Articles
• In vitro evaluation of human cytochrome P450 and P-glycoprotein-mediated metabolism of some phytochemicals in extracts and formulations of African potato  Journal Articles
• In vivo cimetidine inhibits hepatic CYP2C6 and CYP2C11 but not CYP1A1 in adult male rats.  Journal Articles
• Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain  Journal Articles
• Influence of nitric oxide and vasoactive intestinal peptide on the spontaneous and triggered electrical and mechanical activities of the canine ileum  Journal Articles
• Inhibition of Aminoglycoside Antibiotic Resistance Enzymes by Protein Kinase Inhibitors  Journal Articles
• Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis  Journal Articles
• Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives  Journal Articles
• Inhibition of exhaled nitric oxide production during sepsis does not prevent lung inflammation  Journal Articles
• Inhibition of nitric oxide synthase does not prevent ocular dominance plasticity in kitten visual cortex.  Journal Articles
• Inhibition of sporulation, glycopeptide antibiotic production and resistance in Streptomyces toyocaensis NRRL 15009 by protein kinase inhibitors  Journal Articles
• Inhibition of the SAPK/JNK pathway blocks the stimulatory effects of glutamine on fluid secretion by the Malpighian tubules of Rhodnius prolixus  Journal Articles
• Inhibitor Screening Using Immobilized Enzyme Reactor Chromatography/Mass Spectrometry  Journal Articles
• Inhibitor screening of pharmacological chaperones for lysosomal β-glucocerebrosidase by capillary electrophoresis  Journal Articles
• Inhibitors of nitric oxide synthase attenuate nerve growth factor‐mediated increases in choline acetyltransferase expression in PC12 cells  Journal Articles
• Inhibitory effects and mechanisms of intestinal electrical stimulation on gastric tone, antral contractions, pyloric tone, and gastric emptying in dogs  Journal Articles
• Inhibitory effects of tetrandrine and hernandezine on Ca2+ mobilization in rat glioma C6 cells.  Journal Articles
• Insulin Activates a p21-activated Kinase in Muscle Cells via Phosphatidylinositol 3-Kinase  Journal Articles
• Insulin, Insulin-like Growth Factor-I, and Platelet-Derived Growth Factor Activate Extracellular Signal-Regulated Kinase by Distinct Pathways in Muscle Cells  Journal Articles
• Intracellular ion activities in Malpighian tubule cells ofRhodnius prolixus: evaluation of Na+-K+-2Cl-cotransport across the basolateral membrane  Journal Articles
• Isoprostane-induced airway hyperresponsiveness is dependent on internal Ca²⁺ handling and Rho/ROCK signaling  Journal Articles
• K⁺ Transport and Volume Regulatory Response by NKCC in Resting Rat Hindlimb Skeletal Muscle  Journal Articles
• K⁺ transport in resting rat hind-limb skeletal muscle in response to paraxanthine, a caffeine metabolite  Journal Articles
• KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase  Journal Articles
• Kainic acid lesion-induced nigral neuronal death  Journal Articles
• Linear Free Energy Relationship Analysis of Transition State Mimicry by 3-Deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) Oxime, a DAHP Synthase Inhibitor and Phosphate Mimic  Journal Articles
• Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis  Journal Articles
• Maintenance Treatment of Gastroesophageal Reflux Disease: An Evaluation of Continuous and On-Demand Therapy with Rabeprazole 20 mg  Journal Articles
• Matrix Metalloproteinase Inhibitors Suppress Transforming Growth Factor-β-Induced Subcapsular Cataract Formation  Journal Articles
• Measurement of Hepatic Protein Fractional Synthetic Rate with Stable Isotope Labeling Technique in Thapsigargin Stressed HepG2 Cells  Journal Articles
• Mechanism of action of the novel plasma membrane Ca2+-pump inhibitor caloxin  Journal Articles
• Mechanisms of apoptosis induced by purine nucleosides in astrocytes  Journal Articles
• Mechanisms of hydrogen-peroxide-induced biphasic response in rat mesenteric artery.  Journal Articles
• Mechanisms of hydrogen‐peroxide‐induced biphasic response in rat mesenteric artery  Journal Articles
• Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation  Journal Articles
• Metabolism of nilutamide in rat lung  Journal Articles
• Methylene blue treatment for residual symptoms of bipolar disorder: Randomised crossover study  Journal Articles
• Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin M in murine fibroblasts  Journal Articles
• Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis  Journal Articles
• Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide  Journal Articles
• Molecular mechanism of VanHst, an alpha-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism  Journal Articles
• Multiple histidines in the periplasmic domain of the Salmonella enterica sensor kinase SsrA enhance signaling in response to extracellular acidification  Journal Articles
• Multitargeted anti-angiogenic agents and NSCLC: Clinical update and future directions  Journal Articles
• Muscarinic excitation-contraction coupling mechanisms in tracheal and bronchial smooth muscles  Journal Articles
• NAD(P) ⁺ -Malic Enzyme Mutants of Sinorhizobium sp. Strain NGR234, but Not Azorhizobium caulinodans ORS571, Maintain Symbiotic N ₂ Fixation Capabilities  Journal Articles
• Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis  Journal Articles
• Neurite outgrowth in PC12 cells is enhanced by guanosine through both cAMP-dependent and -independent mechanisms  Journal Articles
• Neurotransmission in lower esophageal sphincter ofW/W^vmutant mice  Journal Articles
• New Pharmacologic Approaches in Gastroesophageal Reflux Disease  Journal Articles
• New phenolic inhibitors of yeast homoserine dehydrogenase  Journal Articles
• Nintedanib in patients with idiopathic pulmonary fibrosis and preserved lung volume  Journal Articles
• Nintedanib plus Sildenafil in Patients with Idiopathic Pulmonary Fibrosis  Journal Articles
• Nitrergic and cholinergic vagal pathways involved in the regulation of canine proximal gastric tone: an in vivo study  Journal Articles
• Nitric Oxide Synthase Inhibition Delays Axonal Degeneration and Promotes the Survival of Axotomized Retinal Ganglion Cells  Journal Articles
• Nitric oxide mediates the inhibitory effect of ethanol on the motility of isolated longitudinal muscle of proximal colon in rats  Journal Articles
• Nitric oxide modulates mechanical strain-induced activation of p38 MAPK in mesangial cells  Journal Articles
• Nonribosomal Assembly of Natural Lipocyclocarbamate Lipoprotein‐Associated Phospholipase Inhibitors  Journal Articles
• Novel Approaches to Inhibition of Gastric Acid Secretion  Journal Articles
• Novel males' capacity to disrupt early pregnancy in mice (Mus musculus) is attenuated via a chronic reduction of males' urinary 17β-estradiol  Journal Articles
• Novel targets for valproic acid: up‐regulation of melatonin receptors and neurotrophic factors in C6 glioma cells  Journal Articles
• Novel therapy for COPD  Journal Articles
• Novel therapy for asthma  Journal Articles
• Nucleotide excision repair in the human ovarian carcinoma cell line (2008) and its cisplatin-resistant variant (C13*)  Journal Articles
• OVER THE FENCE  Journal Articles
• Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial  Journal Articles
• Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study  Journal Articles
• Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: Regulation of the type-II IL-4 receptor chains IL-4Rα and IL-13Rα1  Journal Articles
• Oncostatin M induction of eotaxin-1 expression requires the convergence of PI3′K and ERK1/2 MAPK signal transduction pathways  Journal Articles
• Oncostatin M-Induced IL-6 Expression in Murine Fibroblasts Requires the Activation of Protein Kinase Cδ  Journal Articles
• Opposing effects of PKCα and PKCε on basolateral membrane dynamics in intestinal epithelia  Journal Articles
• Ouabain stimulates unidirectional and net potassium efflux in resting mammalian skeletal muscle  Journal Articles
• Ozone Inhalation Provokes Glucocorticoid-Dependent and -Independent Effects on Inflammatory and Metabolic Pathways  Journal Articles
• PROBING EXCITATION‐CONTRACTION COUPLING IN TRACHEALIS SMOOTH MUSCLE WITH THE MYCOTOXIN CYCLOPIAZONIC ACID  Journal Articles
• Pacemaker activity and inhibitory neurotransmission in the colon of Ws/Ws mutant rats  Journal Articles
• Pan-Lysyl Oxidase Inhibitor PXS-5505 Ameliorates Multiple-Organ Fibrosis by Inhibiting Collagen Crosslinks in Rodent Models of Systemic Sclerosis  Journal Articles
• Pathophysiology and management of angiotensin-converting enzyme inhibitor-associated refractory hypotension during the perioperative period.  Journal Articles
• Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anion  Journal Articles
• Peroxide resistance of ER Ca²⁺ pump in endothelium: implications to coronary artery function  Journal Articles
• Peroxynitrite and nitric oxide differ in their effects on pig coronary artery smooth muscle  Journal Articles
• Peroxynitrite resistance of sarco/endoplasmic reticulum Ca2+ pump in pig coronary artery endothelium and smooth muscle  Journal Articles
• Pharmacological evidence that potentiation of plasmalemmal Ca2+-extrusion is functionally coupled to inhibition of SR Ca2+-ATPases in vascular smooth muscle cells  Journal Articles
• Phase I Trial of the Matrix Metalloproteinase Inhibitor Marimastat Combined with Carboplatin and Paclitaxel in Patients with Advanced Non–Small Cell Lung Cancer  Journal Articles
• Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors  Journal Articles
• Phase II/III randomized trial of TCH346 in patients with ALS  Journal Articles
• Phenolic profiles of 20 Canadian lentil cultivars and their contribution to antioxidant activity and inhibitory effects on α-glucosidase and pancreatic lipase  Journal Articles
• Probing the "active site" of diamine oxidase: structure-activity relations for histamine potentiation by O-alkylhydroxylamines on colonic epithelium.  Journal Articles
• Properties of the sarcoplasmic reticulum Ca2+-pump in coronary artery skinned smooth muscle  Journal Articles
• Protein Kinase C and Oxidative Stress in an Animal Model of Mania  Journal Articles
• Protein kinase C plays no role in KCl-induced vascular contraction in Ca(2+)-free medium.  Journal Articles
• Quantification of matrix metalloproteinase activity in plasma of patients enrolled in a BAY 12-9566 phase I study  Journal Articles
• Quantitative analysis of intestinal motor patterns: Spatiotemporal organization of nonneural pacemaker sites in the rat ileum  Journal Articles
• Rapid action of pesticides on cytosolic calcium concentrations in cultures of human umbilical vein endothelial cells  Journal Articles
• Rapid effects of pesticides on human granulosa-lutein cells  Journal Articles
• Regulation of [Ca2+](i) in canine airway smooth muscle by Ca2+-ATPase and Na+/Ca2+ exchange mechanisms  Journal Articles
• Regulation of [Ca2+]i in canine airway smooth muscle by Ca(2+)-ATPase and Na+/Ca2+ exchange mechanisms  Journal Articles
• Regulation of plasminogen activator inhibitor‐1 secretion by urokinase and tissue plasminogen activator in rat epithelioid‐type smooth muscle cells  Journal Articles
• Regulation of slow wave frequency by IP₃-sensitive calcium release in the murine small intestine  Journal Articles
• Relationship between Intracellular Ca2+ Store and Protein Kinase C in Agonist-Induced Contraction of Hypertensive Rat Aortae.  Journal Articles
• Relaxin alters cardiac myofilament function through a PKC-dependent pathway  Journal Articles
• Responsiveness of canine bronchial vasculature to excitatory stimuli and to cooling  Journal Articles
• Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects sperm from DNA damage and apoptosis caused by benzo(a)pyrene  Journal Articles
• Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines  Journal Articles
• Review article: the unmet needs in delayed‐release proton‐pump inhibitor therapy in 2005  Journal Articles
• Role for IL-4 in macromolecular transport across human intestinal epithelium  Journal Articles
• Role of AP-2α Transcription Factor in the Regulation of Synapsin II Gene Expression by Dopamine D1 and D2 Receptors  Journal Articles
• Role of Homoserine Transacetylase as a New Target for Antifungal Agents  Journal Articles
• Role of nitric oxide mechanisms in control of pyloric motility and transpyloric flow of liquids in conscious dogs.  Journal Articles
• Role of signal transducer and activator of transcription 3 (STAT3) in stretch injury to bladder smooth muscle cells  Journal Articles
• Role of sphingolipids in the transport of prosaposin to the lysosomes  Journal Articles
• SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol  Journal Articles
• SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation.  Journal Articles
• Screening of Inhibitors Using Enzymes Entrapped in Sol−Gel-Derived Materials  Journal Articles
• Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids  Journal Articles
• Selective inhibition of oxalate-stimulated Ca²⁺transport by cyclopiazonic acid and thapsigargin in smooth muscle microsomes  Journal Articles
• Selenite Inhibits the c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) through a Thiol Redox Mechanism  Journal Articles
• Shear flow-induced motility ofDictyostelium discoideumcells on solid substrate  Journal Articles
• Short-term exposure to cigarette smoke induces endothelial dysfunction in small intrapulmonary arteries: analysis using guinea pig precision cut lung slices  Journal Articles
• Signaling Aptamers for Monitoring Enzymatic Activity and for Inhibitor Screening  Journal Articles
• Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor  Journal Articles
• Sites of nitric oxide (NO) actions in control of circular muscle motility of the perfused isolated canine ileum  Journal Articles
• Small Structural Differences between Two Ferrocenyl Diphenols Determine Large Discrepancies of Reactivity and Biological Effects  Journal Articles
• Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine  Journal Articles
• Small-Molecule Modulators of Listeria monocytogenes Biofilm Development  Journal Articles
• Small‐Molecule Screening Made Simple for a Difficult Target with a Signaling Nucleic Acid Aptamer that Reports on Deaminase Activity  Journal Articles
• Spontaneous Mn2+ entry is specifically inhibited by calyculin A in human leukemic HL-60 cells  Journal Articles
• Stability or improvement in forced vital capacity with nintedanib in patients with idiopathic pulmonary fibrosis  Journal Articles
• State-of-the-Art-Review : Statins Induce Hypothrombotic States?  Journal Articles
• Storage of thawed plasma for a liquid plasma bank: impact of temperature and methylene blue pathogen inactivation  Journal Articles
• Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria  Journal Articles
• Structure-activity studies on N -Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation  Journal Articles
• Superantigen immune stimulation activates epithelial STAT-1 and PI 3-K: PI 3-K regulation of permeability  Journal Articles
• Superficial buffer barrier and preferentially directed release of Ca²⁺ in canine airway smooth muscle  Journal Articles
• Superficial buffer barrier and preferentially directed release of Ca²⁺in canine airway smooth muscle  Journal Articles
• Superoxide anion mediates angiotensin II-induced potentiation of contractile response to sympathetic stimulation  Journal Articles
• Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy.  Journal Articles
• Symptom relief in gastroesophageal reflux disease: a randomized, controlled comparison of pantoprazole and nizatidine in a mixed patient population with erosive esophagitis or endoscopy-negative reflux disease.  Journal Articles
• Synthesis and Evaluation of Radioiodinated Acyloxymethyl Ketones as Activity-Based Probes for Cathepsin B  Journal Articles
• Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases  Journal Articles
• Synthesis and evaluation of inhibitors of E. coli PgaB, a polysaccharide de-N-acetylase involved in biofilm formation  Journal Articles
• Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (β-Lactones)  Journal Articles
• Systematic review of influenza resistance to the neuraminidase inhibitors  Journal Articles
• TESTOSTERONE PRODUCTION BY ISOLATED RABBIT FOLLICLES IN THE PRESENCE OF LUTEINIZING HORMONE AND INHIBITORS OF STEROIDOGENIC ENZYMES  Journal Articles
• TETRANDRINE AS A CALCIUM ANTAGONIST  Journal Articles
• TGF-β effects on epithelial ion transport and barrier: reduced Cl⁻ secretion blocked by a p38 MAPK inhibitor  Journal Articles
• Targeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease  Journal Articles
• Telomerase, Cell Immortality, and Cancer  Journal Articles
• Thapsigargin decreases the Na+- Ca2+ exchanger mediated Ca2+ entry in pig coronary artery smooth muscle  Journal Articles
• The Second Canadian Gastroesophageal Reflux Disease Consensus: Moving Forward to New Concepts  Journal Articles
• The antiapoptotic effect of guanosine is mediated by the activation of the PI 3‐kinase/AKT/PKB pathway in cultured rat astrocytes  Journal Articles
• The comparative effects of lansoprazole, omeprazole, and ranitidine in suppressing gastric acid secretion  Journal Articles
• The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor  Journal Articles
• The effect of intra-gastric acidity and flora on the concentration of N-nitroso compounds in the stomach  Journal Articles
• The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas—a randomized trial  Journal Articles
• The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells  Journal Articles
• The impact of illness in patients with moderate to severe gastro-esophageal reflux disease  Journal Articles
• The importance of clarithromycin dose in the management of Helicobacter pylori infection: a meta‐analysis of triple therapies with a proton pump inhibitor, clarithromycin and amoxycillin or metronidazole  Journal Articles
• The influence of demographic factors and health-related quality of life on treatment satisfaction in patients with gastroesophageal reflux disease treated with esomeprazole.  Journal Articles
• The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase  Journal Articles
• The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms  Journal Articles
• The myogenic component in distention-induced peristalsis in the guinea pig small intestine  Journal Articles
• The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer  Journal Articles
• The roles of V-type H+-ATPase and Na+/K+-ATPase in energizing K+ and H+ transport in larval Drosophila gut epithelia  Journal Articles
• Therapeutic Efficacy of Allopurinol in Mania Associated With Hyperuricemia  Journal Articles
• Therapeutic targets in idiopathic pulmonary fibrosis  Journal Articles
• Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase  Journal Articles
• To Establish the Efficacy of PPI Therapy for Ulcer Bleeding in the United States, Do We Need More Patients or More PPIs?  Journal Articles
• Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure–Activity Relationships  Journal Articles
• Transport of H+, Na+ and K+ across the posterior midgut of blood-fed mosquitoes (Aedes aegypti)  Journal Articles
• Treatment of Endometriosis with the GnRHa Deslorelin and Add-Back Estradiol and Supplementary Testosterone  Journal Articles
• Treatment of lung cancer via telomerase inhibition: Self-assembled nanoplexes versus polymeric nanoparticles as vectors for 2′-O-Methyl-RNA  Journal Articles
• UDP-N-acetylmuramic Acid (UDP-MurNAc) Is a Potent Inhibitor of MurA (Enolpyruvyl-UDP-GlcNAc Synthase)  Journal Articles
• USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway  Journal Articles
• Using FLIM-FRET to Measure Conformational Changes of Transglutaminase Type 2 in Live Cells  Journal Articles
• Validation of a Short Questionnaire in English and French for Use in Patients with Persistent Upper Gastrointestinal Symptoms Despite Proton Pump Inhibitor Therapy: The Pass (Proton Pump Inhibitor Acid Suppression Symptom) Test  Journal Articles
• Valproate Attenuates Accelerated Atherosclerosis in Hyperglycemic ApoE-Deficient Mice  Journal Articles
• Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3  Journal Articles
• Vanadate, an inhibitor of stromelysin and collagenase expression, suppresses collagen induced arthritis.  Journal Articles
• Vascular effects of Siberian ginseng ( Eleutherococcus senticosus ): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size  Journal Articles
• Vasorelaxant Effects of Pramanicin, an Anti-fungal Agent: Selective Action on Endothelial Cells  Journal Articles
• Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics  Journal Articles
• pH, healing rate, and symptom relief in patients with GERD.  Journal Articles