Enzyme Inhibitors
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1,25-Dihydroxyvitamin D3Primes Acute Promyelocytic Cells for TPA-Induced Monocytic Differentiation through Both PKC and Tyrosine Phosphorylation Cascades Academic Article
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Campylobacter jejuni KDO8P Synthase, Its Inhibition by KDO8P Oxime, and Control of the Residence Time of Slow-Binding Inhibition Academic Article
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L
-NAME inhibits Mg2+
-induced rat aortic relaxation in the absence of endothelium Academic Article
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A Canadian Clinical Practice Algorithm for the Management of Patients with Non-Variceal Upper Gastrointestinal Bleeding Academic Article
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A Double-Blind, Randomized, Placebo-Controlled 4-Week Study on the Efficacy and Safety of the Purinergic Agents Allopurinol and Dipyridamole Adjunctive to Lithium in Acute Bipolar Mania Academic Article
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A Guided Materials Screening Approach for Developing Quantitative Sol-gel Derived Protein Microarrays Academic Article
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A National Cancer Institute of Canada Clinical Trials Group phase II study of eniluracil (776C85) and oral 5-fluorouracil in patients with advanced squamous cell head and neck cancer Academic Article
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A New Target for Antibiotic Development Academic Article
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A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells Academic Article
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A Phase I Open-Label Dose-Escalation Study of Intravenous BI 2536 Together With Pemetrexed in Previously Treated Patients With Non–Small-Cell Lung Cancer Academic Article
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A Phase II Trial with Pharmacodynamic Endpoints of the Proteasome Inhibitor Bortezomib in Patients with Metastatic Colorectal Cancer Academic Article
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A Randomized Trial of Letrozole in Postmenopausal Women after Five Years of Tamoxifen Therapy for Early-Stage Breast Cancer Academic Article
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A Revisitation on the Mechanism of Action of KCI-lnduced Vascular Smooth Muscle Contraction: A Key Role of Cation Binding to the Plasma Membrane Academic Article
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A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions Academic Article
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A matrix-assisted laser desorption/ionization tandem mass spectrometry method for direct screening of small molecule mixtures against an aminoglycoside kinase Academic Article
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A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients. Academic Article
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A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia Academic Article
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A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors Academic Article
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AEG3482 Is an Antiapoptotic Compound that Inhibits Jun Kinase Activity and Cell Death through Induced Expression of Heat Shock Protein 70 Academic Article
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AMP-Activated Protein Kinase-Regulated Activation of the PGC-1α Promoter in Skeletal Muscle Cells Academic Article
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AMPK-independent pathways regulate skeletal muscle fatty acid oxidation Academic Article
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Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents. Academic Article
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Acid–base responses to feeding and intestinal Cl– uptake in freshwater- and seawater-acclimated killifish,Fundulus heteroclitus, an agastric euryhaline teleost Academic Article
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Activation of p38 mitogen-activated protein kinase during normal mitosis in the developing retina Academic Article
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Active site labeling of the gentamicin resistance enzyme AAC(6')-APH(2") by the lipid kinase inhibitor wortmannin Academic Article
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Adenosine-AMP exchange activity is an integral part of the mammalian adenosine kinase Academic Article
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Adropin Is a Novel Regulator of Endothelial Function Conference Paper
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Akt Is Activated in Response to an Apoptotic Signal Academic Article
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American Society of Clinical Oncology Technology Assessment Working Group Update: Use of Aromatase Inhibitors in the Adjuvant Setting Academic Article
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American Society of Clinical Oncology Technology Assessment on the Use of Aromatase Inhibitors as Adjuvant Therapy for Women With Hormone Receptor–Positive Breast Cancer: Status Report 2002 Academic Article
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Aminoglycoside-modifying enzymes Academic Article
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An Expedient and Facile One-Step Synthesis of a Biguanide Library by Microwave Irradiation Coupled with Simple Product Filtration. Inhibitors of Dihydrofolate Reductase Academic Article
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An In Vitro Screen of Bacterial Lipopolysaccharide Biosynthetic Enzymes Identifies an Inhibitor of ADP-Heptose Biosynthesis Academic Article
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An NMR based phosphodiesterase assay Academic Article
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An integrative, in situ approach to examining K+ flux in resting skeletal muscle Academic Article
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Analysis of the interactions between an enzyme and multiple inhibitors using combination plots Academic Article
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Anemia management in chronic kidney disease and dialysis Academic Article
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Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase Academic Article
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Antibiotic Resistance by Enzyme Inactivation: From Mechanisms to Solutions Academic Article
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Antioxidant responses and oxidative stress after microcystin exposure in the hepatopancreas of an estuarine crab species Academic Article
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Apocynum venetum leaf aqueous extract inhibits voltage-gated sodium channels of mouse neuroblastoma N2A cells Academic Article
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Apoptotic Release of Histones from Nucleosomes Academic Article
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Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria Academic Article
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Assessment of the downstream portion of the mitochondrial pathway of caspase activation in patients with acute myeloid leukemia Academic Article
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Autocrine VEGF-A/KDR loop protects epithelial ovarian carcinoma cells from anoikis Academic Article
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BF061, a novel antiplatelet and antithrombotic agent targeting P2Y12 receptor and phosphodiesterase Academic Article
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BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38− cells, through activation of protein kinase Cβ Academic Article
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Binding of Anti-GRP78 Autoantibodies to Cell Surface GRP78 Increases Tissue Factor Procoagulant Activity via the Release of Calcium from Endoplasmic Reticulum Stores Academic Article
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Bleomycin-Induced Lung Toxicity and Pentoxifylline Academic Article
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Ca2+-dependent K+channels and Na+-K+-ATPase mediate H2O2- and superoxide-induced relaxations in canine trachealis Academic Article
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Calcium antagonistic actions of tetrandrine depend on cell types. Academic Article
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Calyculin A-induced endothelial cell shape changes are independent of [Ca2+]i elevation and may involve actin polymerization Academic Article
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Carbon monoxide formation in the ductus arteriosus in the lamb: implications for the regulation of muscle tone Academic Article
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Carbon monoxide-induced relaxation of the ductus arteriosus in the lamb: evidence against the prime role of guanylyl cyclase Academic Article
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Cardiac Sarcomeric Proteins: Novel Intracellular Targets of Matrix Metalloproteinase-2 in Heart Disease Academic Article
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Case 216: Hypertrophic Spinal Pachymeningitis Academic Article
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Catalase activity in coronary artery endothelium protects smooth muscle against peroxide damage Academic Article
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Characterization of Cereulide Synthetase, a Toxin-Producing Macromolecular Machine Academic Article
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Characterization of two members of a novel malic enzyme class Academic Article
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Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane Academic Article
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Chemical biology of tetracycline antibioticsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process. Academic Article
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Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology Academic Article
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Chronic Nicotine Blunts Hypoxic Sensitivity in Perinatal Rat Adrenal Chromaffin Cells via Upregulation of KATPChannels: Role of α7 Nicotinic Acetylcholine Receptor and Hypoxia-Inducible Factor-2α Academic Article
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Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A Academic Article
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Clinically relevant concentrations of valproic acid modulate melatonin MT1 receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells Academic Article
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Combination plots as graphical tools in the study of enzyme inhibition Academic Article
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Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21WAF1/CIP1 and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity Academic Article
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Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions Academic Article
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Control of Motoneuron Survival by Angiogenin Academic Article
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Cooperation in signal transduction of extracellular guanosine 5′ triphosphate and nerve growth factor in neuronal differentiation of PC12 cells Academic Article
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Copper effects on key metabolic enzymes and mitochondrial membrane potential in gills of the estuarine crab Neohelice granulata at different salinities Academic Article
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Coronary artery wall shear stress is associated with endothelial dysfunction and expansive arterial remodelling in patients with coronary artery disease Academic Article
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Cost-Effectiveness and Cost-Utility of Long-Term Management Strategies for Heartburn Academic Article
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Covalently linking heparin to antithrombin enhances prothrombinase inhibition on activated platelets Academic Article
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Crosstalk between Notch and Sonic hedgehog signaling in a mouse model of amyotrophic lateral sclerosis Academic Article
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Curcumin prevents haloperidol-induced development of abnormal oro-facial movements: Possible implications of Bcl-XL in its mechanism of action Academic Article
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Cyclopiazonic acid and thapsigargin induce platelet aggregation resulting from Ca2+ influx through Ca2+ store-activated Ca2+- channels Academic Article
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Cyclopiazonic acid, inhibiting the endoplasmic reticulum calcium pump, reduces the canine colonic pacemaker frequency. Academic Article
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Cystathionine β-Lyase Is Important for Virulence of
Salmonella enterica
Serovar Typhimurium Academic Article
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Cytochrome P450 3A4 Inhibitory Activity Studies within the Lycorine series of Alkaloids Academic Article
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Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis Academic Article
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DNA methyltransferase inhibitors—state of the art Academic Article
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Deficiency of intramuscular ICC increases fundic muscle excitability but does not impede nitrergic innervation Academic Article
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Demonstration in vitro of two intracellular inactivators of nitrate reductase from Neurospora Academic Article
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Determination of 4-hydroxyproline-2-epimerase activity by capillary electrophoresis: A stereoselective platform for inhibitor screening of amino acid isomerases Academic Article
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Determination of the molecular states of the processive endocellulase Thermobifida fusca Cel9A during crystalline cellulose depolymerization Academic Article
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Development of New Deoxycytidine Kinase Inhibitors and Noninvasive in Vivo Evaluation Using Positron Emission Tomography Academic Article
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Development of a continuous assay for the measurement of tissue factor procoagulant activity on intact cells Academic Article
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Development, implementation, and evaluation of a ketoconazole practice guideline for ARDS prophylaxis Academic Article
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Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration Academic Article
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Direct Thrombin Inhibitors in Acute Coronary Syndromes Academic Article
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Distinct Properties of the Two Isoforms of CDP-Diacylglycerol Synthase Academic Article
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Do aromatase inhibitors increase cardiovascular risk? Piecing together the evidence Academic Article
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Duration of effect of lansoprazole on gastric pH and acid secretion in normal male volunteers Academic Article
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EGFR-PLCγ1 signaling mediates high glucose-induced PKCβ1-Akt activation and collagen I upregulation in mesangial cells Academic Article
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ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function Academic Article
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ETV5 as a regulator of matrix metalloproteinase 2 in human chondrosarcoma Academic Article
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Effect of Atrial Fibrillation on Atrial Thrombogenesis in Humans: Impact of Rate and Rhythm Academic Article
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Effect of Omeprazole on Regional and Temporal Variations in Intragastric Acidity Academic Article
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Effect of Th1 cytokines on acid secretion in pharmacologically characterised mouse gastric glands Academic Article
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Effect of delivery of MMP inhibitors from PDMS as a model IOL material on PCO markers Academic Article
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Effect of surgeon on outcome of antireflux surgery Conference Paper
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Effects of Cytochrome P450 Inhibitors on the Biotransformation of Fluorogenic Substrates by Adult Male Rat Liver Microsomes and cDNA-Expressed Rat Cytochrome P450 Isoforms Academic Article
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Effects of cortisol and oestradiol on hepatic 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor proteins in late-gestation sheep fetus Academic Article
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Effects of geldanamycin on HIF-1α mediated angiogenesis and invasion in prostate cancer cells Academic Article
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Effects of methyl parathion on Chasmagnathus granulatus hepatopancreas: Protective role of Sesamol Academic Article
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Effects of peroxynitrite on pig coronary artery smooth muscle Academic Article
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Effects of peroxynitrite on sarcoplasmic reticulum Ca2+pump in pig coronary artery smooth muscle Academic Article
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Effects of some isoprostanes on the human umbilical arteryin vitro Academic Article
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Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension Academic Article
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Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis Academic Article
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Efficacy and safety of nintedanib in patients with advanced idiopathic pulmonary fibrosis Academic Article
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Eliminating Competition: Characterizing and Eliminating Competitive Binding at Separate Sites between DAHP Synthase’s Essential Metal Ion and the Inhibitor DAHP Oxime Academic Article
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Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3β Activation in Apolipoprotein E–Deficient Mouse Models of Accelerated Atherosclerosis Academic Article
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Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2 Academic Article
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Endothelial NOS, estrogen receptor β, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer Academic Article
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Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase Academic Article
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Epigenetic induction of melatonin MT 1 receptors by valproate: Neurotherapeutic implications Academic Article
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Esomeprazole 20 mg vs. pantoprazole 20 mg for maintenance therapy of healed erosive oesophagitis: results from the EXPO study1 Academic Article
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Estrogen Receptor-α and Endothelial Nitric Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase Academic Article
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Etiology of Dyspepsia: Implication for Empiric Therapy Academic Article
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Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds Academic Article
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Exploring Pluripotency with Chemical Genetics Academic Article
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Expression of p27 in Residual Rectal Cancer after Preoperative Chemoradiation Predicts Long-term Outcome Academic Article
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Extracellular guanosine 5′ triphosphate enhances nerve growth factor-induced neurite outgrowth via increases in intracellular calcium Academic Article
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FGF-2-induced Negative Inotropism and Cardioprotection are Inhibited by Chelerythrine: Involvement of Sarcolemmal Calcium-independent Protein Kinase C Academic Article
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Finasteride-Induced Myalgia and HyperCKemia Academic Article
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First Data on Efficacy and Safety of Nintedanib in Patients with Idiopathic Pulmonary Fibrosis and Forced Vital Capacity of ≤50 % of Predicted Value Academic Article
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GERD 2003 – A Consensus on the Way Ahead Academic Article
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Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer Academic Article
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Gatekeeping versus Promiscuity in the Early Stages of the Andrimid Biosynthetic Assembly Line Academic Article
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Generation of slow waves in membrane potential is an intrinsic property of interstitial cells of Cajal Academic Article
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Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity Academic Article
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Giardia lamblia RNA Polymerase II Academic Article
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Glucosamine induces ER stress by disrupting lipid-linked oligosaccharide biosynthesis andN-linked protein glycosylation Academic Article
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Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation Academic Article
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Guanosine protects SH-SY5Y cells against β-amyloid-induced apoptosis Academic Article
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Heparin Synergistically Enhances Interleukin-11 Signaling through Up-regulation of the MAPK Pathway Academic Article
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Heteroactivation of cytochrome P450 1A1 by teas and tea polyphenols Academic Article
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High quality drug screening by capillary electrophoresis: A review Academic Article
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High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones Academic Article
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Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid Academic Article
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Hydrogen peroxide induces a greater contraction in mesenteric arteries of spontaneously hypertensive rats through thromboxane A2
production Academic Article
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Identification and Biochemical Studies on Novel Non-Nucleoside Inhibitors of the Enzyme Adenosine Kinase Academic Article
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Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase Academic Article
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Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells Academic Article
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Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry Academic Article
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Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity Academic Article
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Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation Academic Article
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Impairment of pyruvate dehydrogenase activity by acetaldehyde Academic Article
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Implication of a Nitric Oxide Synthase Mechanism in the Action of Substance P: L-NAME Blocks Thermal Hyperalgesia Induced by Endogenous and Exogenous Substance P in the Rat Academic Article
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In vitro evaluation of human cytochrome P450 and P-glycoprotein-mediated metabolism of some phytochemicals in extracts and formulations of African potato Academic Article
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In vivo cimetidine inhibits hepatic CYP2C6 and CYP2C11 but not CYP1A1 in adult male rats. Academic Article
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Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain Academic Article
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Influence of nitric oxide and vasoactive intestinal peptide on the spontaneous and triggered electrical and mechanical activities of the canine ileum Academic Article
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Inhibition of Aminoglycoside Antibiotic Resistance Enzymes by Protein Kinase Inhibitors Academic Article
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Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis Academic Article
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Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives Academic Article
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Inhibition of exhaled nitric oxide production during sepsis does not prevent lung inflammation Academic Article
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Inhibition of nitric oxide synthase does not prevent ocular dominance plasticity in kitten visual cortex. Academic Article
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Inhibition of sporulation, glycopeptide antibiotic production and resistance in Streptomyces toyocaensis NRRL 15009 by protein kinase inhibitors Academic Article
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Inhibitor Screening Using Immobilized Enzyme Reactor Chromatography/Mass Spectrometry Academic Article
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Inhibitor screening of pharmacological chaperones for lysosomal β-glucocerebrosidase by capillary electrophoresis Academic Article
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Inhibitors of nitric oxide synthase attenuate nerve growth factor-mediated increases in choline acetyltransferase expression in PC12 cells Academic Article
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Inhibitory effects and mechanisms of intestinal electrical stimulation on gastric tone, antral contractions, pyloric tone, and gastric emptying in dogs Academic Article
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Inhibitory effects of tetrandrine and hernandezine on Ca2+ mobilization in rat glioma C6 cells. Academic Article
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Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions Academic Article
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Insulin Activates a p21-activated Kinase in Muscle Cells via Phosphatidylinositol 3-Kinase Academic Article
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Insulin, Insulin-like Growth Factor-I, and Platelet-Derived Growth Factor Activate Extracellular Signal-Regulated Kinase by Distinct Pathways in Muscle Cells Academic Article
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Introduction to the special issue: Inhibitors of enzymes involved in lipid metabolism Academic Article
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Isoprostane-induced airway hyperresponsiveness is dependent on internal Ca2+ handling and Rho/ROCK signaling Academic Article
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K<sup>+</sup> Transport and Volume Regulatory Response by NKCC in Resting Rat Hindlimb Skeletal Muscle Academic Article
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K+ transport in resting rat hind-limb skeletal muscle in response to paraxanthine, a caffeine metabolite Academic Article
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KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase Academic Article
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Kainic acid lesion-induced nigral neuronal death Academic Article
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Linear Free Energy Relationship Analysis of Transition State Mimicry by 3-Deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) Oxime, a DAHP Synthase Inhibitor and Phosphate Mimic Academic Article
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Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis Academic Article
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Maintenance Treatment of Gastroesophageal Reflux Disease: An Evaluation of Continuous and On-Demand Therapy with Rabeprazole 20 mg Academic Article
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Matrix Metalloproteinase Inhibitors Suppress Transforming Growth Factor-β-Induced Subcapsular Cataract Formation Academic Article
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Mechanism of action of the novel plasma membrane Ca2+-pump inhibitor caloxin Academic Article
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Mechanisms of apoptosis induced by purine nucleosides in astrocytes Academic Article
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Mechanisms of hydrogen-peroxide-induced biphasic response in rat mesenteric artery. Academic Article
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Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation Academic Article
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Metabolism of nilutamide in rat lung Academic Article
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Methaemoglobinaemia following ingestion of a commonly available food additive Academic Article
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Methylene blue treatment for residual symptoms of bipolar disorder: Randomised crossover study Academic Article
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Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin M in murine fibroblasts Academic Article
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Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis Academic Article
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Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide Academic Article
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Molecular mechanism of VanHst, an alpha-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism Academic Article
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Multiple histidines in the periplasmic domain of theSalmonella entericasensor kinase SsrA enhance signaling in response to extracellular acidification Academic Article
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Multitargeted anti-angiogenic agents and NSCLC: Clinical update and future directions Academic Article
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Muscarinic excitation-contraction coupling mechanisms in tracheal and bronchial smooth muscles Academic Article
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NAD(P)
+
-Malic Enzyme Mutants of Sinorhizobium sp. Strain NGR234, but Not Azorhizobium caulinodans ORS571, Maintain Symbiotic N
2
Fixation Capabilities Academic Article
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Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis Academic Article
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Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1 Academic Article
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Neurite outgrowth in PC12 cells is enhanced by guanosine through both cAMP-dependent and -independent mechanisms Academic Article
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Neurotransmission in lower esophageal sphincter ofW/Wvmutant mice Academic Article
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New Pharmacologic Approaches in Gastroesophageal Reflux Disease Academic Article
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New phenolic inhibitors of yeast homoserine dehydrogenase Academic Article
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Nintedanib in patients with idiopathic pulmonary fibrosis and preserved lung volume Academic Article
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Nintedanib plus Sildenafil in Patients with Idiopathic Pulmonary Fibrosis Academic Article
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Nitrergic and cholinergic vagal pathways involved in the regulation of canine proximal gastric tone: an in vivo study Academic Article
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Nitric Oxide Synthase Inhibition Delays Axonal Degeneration and Promotes the Survival of Axotomized Retinal Ganglion Cells Academic Article
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Nitric oxide mediates the inhibitory effect of ethanol on the motility of isolated longitudinal muscle of proximal colon in rats Academic Article
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Nitric oxide modulates mechanical strain-induced activation of p38 MAPK in mesangial cells Academic Article
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Nonribosomal Assembly of Natural Lipocyclocarbamate Lipoprotein-Associated Phospholipase Inhibitors Academic Article
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Novel Approaches to Inhibition of Gastric Acid Secretion Academic Article
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Novel males' capacity to disrupt early pregnancy in mice (Mus musculus) is attenuated via a chronic reduction of males' urinary 17β-estradiol Academic Article
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Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells Academic Article
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Novel therapy for COPD Academic Article
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Novel therapy for asthma Academic Article
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Nucleotide excision repair in the human ovarian carcinoma cell line (2008) and its cisplatin-resistant variant (C13*) Academic Article
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OVER THE FENCE Academic Article
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Oestrogen receptor downregulation: an opportunity for extending the window of endocrine therapy in advanced breast cancer Academic Article
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Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: Regulation of the type-II IL-4 receptor chains IL-4Rα and IL-13Rα1 Academic Article
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Oncostatin M induction of eotaxin-1 expression requires the convergence of PI3′K and ERK1/2 MAPK signal transduction pathways Academic Article
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Oncostatin M-Induced IL-6 Expression in Murine Fibroblasts Requires the Activation of Protein Kinase Cδ Academic Article
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Opposing effects of PKCα and PKCε on basolateral membrane dynamics in intestinal epithelia Academic Article
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Orotidine Monophosphate Decarboxylase – A Fascinating Workhorse Enzyme with Therapeutic Potential Academic Article
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Ouabain stimulates unidirectional and net potassium efflux in resting mammalian skeletal muscle Academic Article
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Ozone Inhalation Provokes Glucocorticoid-Dependent and -Independent Effects on Inflammatory and Metabolic Pathways Academic Article
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PROBING EXCITATION-CONTRACTION COUPLING IN TRACHEALIS SMOOTH MUSCLE WITH THE MYCOTOXIN CYCLOPIAZONIC ACID Academic Article
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Pacemaker activity and inhibitory neurotransmission in the colon of Ws/Ws mutant rats Academic Article
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Pan-Lysyl Oxidase Inhibitor PXS-5505 Ameliorates Multiple-Organ Fibrosis by Inhibiting Collagen Crosslinks in Rodent Models of Systemic Sclerosis Academic Article
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Pathophysiology and management of angiotensin-converting enzyme inhibitor-associated refractory hypotension during the perioperative period. Academic Article
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Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anion Academic Article
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Peroxide resistance of ER Ca2+pump in endothelium: implications to coronary artery function Academic Article
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Peroxynitrite and nitric oxide differ in their effects on pig coronary artery smooth muscle Academic Article
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Peroxynitrite resistance of sarco/endoplasmic reticulum Ca2+ pump in pig coronary artery endothelium and smooth muscle Academic Article
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Pharmacological evidence that potentiation of plasmalemmal Ca2+-extrusion is functionally coupled to inhibition of SR Ca2+-ATPases in vascular smooth muscle cells Academic Article
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Phase I Trial of the Matrix Metalloproteinase Inhibitor Marimastat Combined with Carboplatin and Paclitaxel in Patients with Advanced Non–Small Cell Lung Cancer Academic Article
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Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors Academic Article
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Phase II/III randomized trial of TCH346 in patients with ALS Academic Article
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Phenolic profiles of 20 Canadian lentil cultivars and their contribution to antioxidant activity and inhibitory effects on α-glucosidase and pancreatic lipase Academic Article
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Probing the "active site" of diamine oxidase: structure-activity relations for histamine potentiation by O-alkylhydroxylamines on colonic epithelium. Academic Article
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Properties of the sarcoplasmic reticulum Ca2+-pump in coronary artery skinned smooth muscle Academic Article
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Protein Kinase C and Oxidative Stress in an Animal Model of Mania Academic Article
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Protein kinase C plays no role in KCl-induced vascular contraction in Ca(2+)-free medium. Academic Article
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Quantification of matrix metalloproteinase activity in plasma of patients enrolled in a BAY 12-9566 phase I study Academic Article
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Quantitative analysis of intestinal motor patterns: Spatiotemporal organization of nonneural pacemaker sites in the rat ileum Academic Article
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Rapid action of pesticides on cytosolic calcium concentrations in cultures of human umbilical vein endothelial cells Academic Article
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Rapid effects of pesticides on human granulosa-lutein cells Academic Article
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Regulation of [Ca2+]i in canine airway smooth muscle by Ca(2+)-ATPase and Na+/Ca2+ exchange mechanisms Academic Article
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Regulation of plasminogen activator inhibitor-1 secretion by urokinase and tissue plasminogen activator in rat epithelioid-type smooth muscle cells Academic Article
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Regulation of slow wave frequency by IP3-sensitive calcium release in the murine small intestine Academic Article
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Relationship between Intracellular Ca2+ Store and Protein Kinase C in Agonist-Induced Contraction of Hypertensive Rat Aortae. Academic Article
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Relaxin alters cardiac myofilament function through a PKC-dependent pathway Academic Article
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Responsiveness of canine bronchial vasculature to excitatory stimuli and to cooling Academic Article
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Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects sperm from DNA damage and apoptosis caused by benzo(a)pyrene Academic Article
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Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines Academic Article
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Review article: the unmet needs in delayed-release proton-pump inhibitor therapy in 2005 Academic Article
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Role for IL-4 in macromolecular transport across human intestinal epithelium Academic Article
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Role of AP-2α Transcription Factor in the Regulation of Synapsin II Gene Expression by Dopamine D1 and D2 Receptors Academic Article
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Role of Homoserine Transacetylase as a New Target for Antifungal Agents Academic Article
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Role of nitric oxide mechanisms in control of pyloric motility and transpyloric flow of liquids in conscious dogs. Academic Article
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Role of signal transducer and activator of transcription 3 (STAT3) in stretch injury to bladder smooth muscle cells Academic Article
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Role of sphingolipids in the transport of prosaposin to the lysosomes Academic Article
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SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol Academic Article
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Screening of Inhibitors Using Enzymes Entrapped in Sol−Gel-Derived Materials Academic Article
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Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids Academic Article
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Selective inhibition of oxalate-stimulated Ca2+transport by cyclopiazonic acid and thapsigargin in smooth muscle microsomes Academic Article
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Shear flow-induced motility ofDictyostelium discoideumcells on solid substrate Academic Article
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Short-term exposure to cigarette smoke induces endothelial dysfunction in small intrapulmonary arteries: analysis using guinea pig precision cut lung slices Academic Article
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Signaling Aptamers for Monitoring Enzymatic Activity and for Inhibitor Screening Academic Article
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Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor Academic Article
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Sites of nitric oxide (NO) actions in control of circular muscle motility of the perfused isolated canine ileum Academic Article
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Small Structural Differences between Two Ferrocenyl Diphenols Determine Large Discrepancies of Reactivity and Biological Effects Academic Article
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Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine Academic Article
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Small-Molecule Modulators of Listeria monocytogenes Biofilm Development Academic Article
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Small-Molecule Screening Made Simple for a Difficult Target with a Signaling Nucleic Acid Aptamer that Reports on Deaminase Activity Academic Article
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Spontaneous Mn2+ entry is specifically inhibited by calyculin A in human leukemic HL-60 cells Academic Article
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Stability or improvement in forced vital capacity with nintedanib in patients with idiopathic pulmonary fibrosis Academic Article
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State-of-the-Art-Review : Statins Induce Hypothrombotic States? Academic Article
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Storage of thawed plasma for a liquid plasma bank: impact of temperature and methylene blue pathogen inactivation Academic Article
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Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria Academic Article
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Structural determinants for the inhibitory ligands of orotidine-5′-monophosphate decarboxylase Academic Article
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Structure-activity studies on N -Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation Academic Article
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Substrate specificity of diacylglycerol kinase-epsilon and the phosphatidylinositol cycle Academic Article
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Superantigen immune stimulation activates epithelial STAT-1 and PI 3-K: PI 3-K regulation of permeability Academic Article
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Superficial buffer barrier and preferentially directed release of Ca2+in canine airway smooth muscle Academic Article
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Superoxide anion mediates angiotensin II-induced potentiation of contractile response to sympathetic stimulation Academic Article
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Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy. Academic Article
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Symptom relief in gastroesophageal reflux disease: a randomized, controlled comparison of pantoprazole and nizatidine in a mixed patient population with erosive esophagitis or endoscopy-negative reflux disease. Academic Article
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Synthesis and Evaluation of Radioiodinated Acyloxymethyl Ketones as Activity-Based Probes for Cathepsin B Academic Article
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Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases Academic Article
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Synthesis and evaluation of inhibitors of E. coli PgaB, a polysaccharide de-N-acetylase involved in biofilm formation Academic Article
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Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (β-Lactones) Academic Article
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Systematic review of influenza resistance to the neuraminidase inhibitors Academic Article
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TESTOSTERONE PRODUCTION BY ISOLATED RABBIT FOLLICLES IN THE PRESENCE OF LUTEINIZING HORMONE AND INHIBITORS OF STEROIDOGENIC ENZYMES Academic Article
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TETRANDRINE AS A CALCIUM ANTAGONIST Academic Article
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TGF-β effects on epithelial ion transport and barrier: reduced Cl−secretion blocked by a p38 MAPK inhibitor Academic Article
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Targeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease Academic Article
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Telomerase, Cell Immortality, and Cancer Academic Article
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Thapsigargin decreases the Na+- Ca2+ exchanger mediated Ca2+ entry in pig coronary artery smooth muscle Academic Article
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The Apoptotic Protein tBid Promotes Leakage by Altering Membrane Curvature Academic Article
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The Second Canadian Gastroesophageal Reflux Disease Consensus: Moving Forward to New Concepts Academic Article
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The antiapoptotic effect of guanosine is mediated by the activation of the PI 3-kinase/AKT/PKB pathway in cultured rat astrocytes Academic Article
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The comparative effects of lansoprazole, omeprazole, and ranitidine in suppressing gastric acid secretion Academic Article
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The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor Academic Article
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The effect of intra-gastric acidity and flora on the concentration of N-nitroso compounds in the stomach Academic Article
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The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas—a randomized trial Academic Article
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The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells Academic Article
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The impact of illness in patients with moderate to severe gastro-esophageal reflux disease Academic Article
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The importance of clarithromycin dose in the management ofHelicobacter pyloriinfection: a meta-analysis of triple therapies with a proton pump inhibitor, clarithromycin and amoxycillin or metronidazole Academic Article
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The influence of demographic factors and health-related quality of life on treatment satisfaction in patients with gastroesophageal reflux disease treated with esomeprazole. Academic Article
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The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase Academic Article
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The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms Academic Article
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The myogenic component in distention-induced peristalsis in the guinea pig small intestine Academic Article
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The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer Academic Article
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The role of tamoxifen and aromatase inhibitors/inactivators in postmenopausal patients. Academic Article
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The roles of V-type H+-ATPase and Na+/K+-ATPase in energizing K+ and H+ transport in larval Drosophila gut epithelia Academic Article
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The ε Subtype of Protein Kinase C Is Required for Cardiomyocyte Connexin-43 Phosphorylation Academic Article
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Therapeutic Efficacy of Allopurinol in Mania Associated With Hyperuricemia Academic Article
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Therapeutic targets in idiopathic pulmonary fibrosis Academic Article
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Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase Academic Article
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To Establish the Efficacy of PPI Therapy for Ulcer Bleeding in the United States, Do We Need More Patients or More PPIs? Academic Article
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Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure-Activity Relationships Academic Article
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Transbilayer inhibition of protein kinase C by the lipophosphoglycan from Leishmania donovani. Academic Article
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Transport of H+, Na+ and K+ across the posterior midgut of blood-fed mosquitoes (Aedes aegypti) Academic Article
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Treatment of Endometriosis with the GnRHa Deslorelin and Add-Back Estradiol and Supplementary Testosterone Academic Article
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Treatment of lung cancer via telomerase inhibition: Self-assembled nanoplexes versus polymeric nanoparticles as vectors for 2′-O-Methyl-RNA Academic Article
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UDP-N-acetylmuramic Acid (UDP-MurNAc) Is a Potent Inhibitor of MurA (Enolpyruvyl-UDP-GlcNAc Synthase) Academic Article
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USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway Academic Article
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Using FLIM-FRET to Measure Conformational Changes of Transglutaminase Type 2 in Live Cells Academic Article
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Validation of a Short Questionnaire in English and French for Use in Patients with Persistent Upper Gastrointestinal Symptoms Despite Proton Pump Inhibitor Therapy: The Pass (Proton Pump Inhibitor Acid Suppression Symptom) Test Academic Article
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Valproate Attenuates Accelerated Atherosclerosis in Hyperglycemic ApoE-Deficient Mice Academic Article
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Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3 Academic Article
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Vanadate, an inhibitor of stromelysin and collagenase expression, suppresses collagen induced arthritis. Academic Article
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Vascular effects of Siberian ginseng ( Eleutherococcus senticosus ): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size Academic Article
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Vasorelaxant Effects of Pramanicin, an Anti-fungal Agent: Selective Action on Endothelial Cells Academic Article
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Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics Academic Article
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pH, healing rate, and symptom relief in patients with GERD. Academic Article