Journal article
Assessment of the downstream portion of the mitochondrial pathway of caspase activation in patients with acute myeloid leukemia
Abstract
Most chemotherapeutic agents used in the treatment of acute myeloid leukemia (AML) induce apoptosis by triggering the mitochondrial pathway of caspase activation. To investigate the downstream portion of the mitochondrial pathway of caspase activation in patients with AML, cytosolic lysates were stimulated with cytochrome c and dATP and hydrolysis of Ac-DEVD-AFC by effector caspases was measured. Defects in the distal mitochondrial pathway were …
Authors
Gronda M; Brandwein J; Minden MD; Pond GR; Schuh AC; Wells RA; Messner H; Chun K; Schimmer AD
Journal
Apoptosis, Vol. 10, No. 6, pp. 1285–1294
Publisher
Springer Nature
Publication Date
December 2005
DOI
10.1007/s10495-005-2764-4
ISSN
1360-8185