Journal article
Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase
Abstract
The aspartate pathway in fungi is a well‐validated antimicrobial target. Deletion of homoserine kinase (THR1) has been proven to lead to a chemical‐synthetic lethal phenotype in the presence of several bioactive molecules. We have identified and characterized several Thr1 inhibitors that can be used in combination therapy against fungal infections.
Authors
De Pascale G; Griffiths EJ; Shakya T; Nazi I; Wright GD
Journal
ChemBioChem, Vol. 12, No. 8, pp. 1179–1182
Publisher
Wiley
Publication Date
May 16, 2011
DOI
10.1002/cbic.201100121
ISSN
1439-4227