Scholarly Works

Identification and Characterization of New...

Journal article

Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase

Abstract

The aspartate pathway in fungi is a well‐validated antimicrobial target. Deletion of homoserine kinase (THR1) has been proven to lead to a chemical‐synthetic lethal phenotype in the presence of several bioactive molecules. We have identified and characterized several Thr1 inhibitors that can be used in combination therapy against fungal infections.

Authors

De Pascale G; Griffiths EJ; Shakya T; Nazi I; Wright GD

Journal

ChemBioChem, Vol. 12, No. 8, pp. 1179–1182

Publisher

Wiley

Publication Date

May 16, 2011

DOI

10.1002/cbic.201100121

ISSN

1439-4227

Associated Experts

Gerard Wright

Scientific Director, Faculty of Health Sciences

Ishac Nazy

Professor, Faculty of Health Sciences

Labels

Fields of Research (FoR)

3107 Microbiology 31 Biological Sciences 3101 Biochemistry and cell biology 3404 Medicinal and biomolecular chemistry

Medical Subject Headings (MeSH)

Antifungal Agents Binding, Competitive Cloning, Molecular Enzyme Inhibitors Microbial Sensitivity Tests Models, Biological Molecular Structure Phosphotransferases (Alcohol Group Acceptor)Schizosaccharomyces Signal Transduction Small Molecule Libraries

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