Journal article
Effect of delivery of MMP inhibitors from PDMS as a model IOL material on PCO markers
Abstract
Posterior capsule opacification (PCO) or secondary cataract formation, following intraocular lens implantation, is a significant complication affecting an estimated 28% of cataract patients. Matrix metalloproteinases (MMPs) have been demonstrated to play a role in the formation of anterior subcapsular cataracts and it has been shown that the presence of MMP inhibitors (MMPI) decreases subcapsular cataract formation ex vivo. Since the mechanisms …
Authors
Morarescu D; West-Mays JA; Sheardown HD
Journal
Biomaterials, Vol. 31, No. 8, pp. 2399–2407
Publisher
Elsevier
Publication Date
3 2010
DOI
10.1016/j.biomaterials.2009.11.108
ISSN
0142-9612
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBiocompatible MaterialsBiomarkersCataractCells, CulturedDrug CarriersDrug Delivery SystemsEnzyme InhibitorsEpithelial CellsHumansIsoenzymesLens Capsule, CrystallineLenses, IntraocularMaterials TestingMatrix Metalloproteinase InhibitorsMolecular StructureRetinal Pigment EpitheliumSilicone Elastomers