Journal article
High quality drug screening by capillary electrophoresis: A review
Abstract
High quality assays are needed in drug discovery to reduce the high attrition rate of lead compounds during primary screening. Capillary electrophoresis (CE) represents a versatile micro-separation technique for resolution of enzyme-catalyzed reactions, including substrate(s), product(s), cofactor(s) and their stereoisomers, which is needed for reliable characterization of biomolecular interactions in free solution. This review article provides …
Authors
Shanmuganathan M; Britz-McKibbin P
Journal
Analytica Chimica Acta, Vol. 773, , pp. 24–36
Publisher
Elsevier
Publication Date
April 2013
DOI
10.1016/j.aca.2013.01.061
ISSN
0003-2670