Review article: the unmet needs in delayed‐release proton‐pump inhibitor therapy in 2005

SummaryProton‐pump inhibitors have been highly effective in managing acid‐related gastrointestinal disorders, but challenges remain. This paper reviews the challenges in the management of patients with gastro‐oesophageal symptoms who do not respond adequately to proton‐pump inhibitor therapy; the treatment of patients with non‐variceal upper gastrointestinal bleeding; the prevention of stress‐related mucosal bleeding; the treatment and prevention of non‐steroidal anti‐inflammatory drug‐related gastrointestinal injury; and the optimal combination of antisecretory and antibiotic therapy for the eradication of Helicobacter pylori infection, all of which represent unmet clinical needs.Antisecretory therapy with a rapid onset of action and sustained antisecretory effect may help to address some of the unmet needs discussed, especially in the management of gastro‐oesophageal reflux disease, non‐variceal upper gastrointestinal bleeding and non‐steroidal anti‐inflammatory drug‐related gastrointestinal complications.

Review article: the unmet needs in delayed‐release proton‐pump inhibitor therapy in 2005 Journal Articles