Autocrine VEGF‐A/KDR loop protects epithelial...

Abstract

Epithelial ovarian carcinoma (EOC) patients are usually diagnosed at an advanced stage, characterized by interperitoneal carcinomatosis and production of large volumes of ascites. Vascular endothelial growth factor-A (VEGF-A) and its main signaling receptor VEGFR2 (KDR) are coexpressed in primary ovarian tumors, ascitic cells and metastases, suggesting the existence of an autocrine VEGF-A/KDR loop in EOC cells. In the present study, we examined …

Authors

Sher I; Adham SA; Petrik J; Coomber BL

Journal

International Journal of Cancer, Vol. 124, No. 3, pp. 553–561

Publisher

Wiley

Publication Date

2 2009

DOI

10.1002/ijc.23963

ISSN

0020-7136

Associated Experts

James Petrik

Professor (Part-Time), Faculty of Health Sciences

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Labels

Fields of Research (FoR)

32 Biomedical and Clinical Sciences 3211 Oncology and carcinogenesis

Medical Subject Headings (MeSH)

Anoikis Autocrine Communication Blotting, Western Cell Line, Tumor Enzyme Inhibitors Enzyme-Linked Immunosorbent Assay Epithelial Cells Female Fluorescent Antibody Technique Humans Immunoprecipitation In Situ Nick-End Labeling Neoplasms, Glandular and Epithelial Ovarian Neoplasms RNA, Messenger Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-2

Autocrine VEGF‐A/KDR loop protects epithelial ovarian carcinoma cells from anoikis