Journal article
Metabolism of nilutamide in rat lung
Abstract
Nilutamide is a non-steroidal anti-androgen drug proposed in the treatment of metastatic prostatic carcinoma. Its therapeutic effects are overshadowed by the occurrence of adverse reactions, mediated by mechanisms that remain elusive. To elucidate possible mechanisms for nilutamide toxicity, we investigated the metabolism of nilutamide in rat lung homogenates, in subcellular fractions and in freshly isolated cells. In whole lung homogenates, …
Authors
Ask K; Décologne N; Ginies C; Låg M; Boucher JL; Holme JA; Pelczar H; Camus P
Journal
Biochemical Pharmacology, Vol. 71, No. 3, pp. 377–385
Publisher
Elsevier
Publication Date
January 2006
DOI
10.1016/j.bcp.2005.10.034
ISSN
0006-2952